The aim of this study was to evaluate the effects of lactoferrin (Lf) on growth and feeding performance, biochemical and immune parameters in Asian sea bass (Lates calcarifer). A basal diet was supplemented with 0 (control), 400 (400 Lf), or 800 (800 Lf) mg Lf kg⁻¹ diet. The results indicate a significant increase in innate immune parameters when the diet was supplemented with 800 mg Lf kg⁻¹. The highest serum albumin value and the lowest serum glucose concentration were observed in 800 Lf group. The liver catalase activity in the 400 Lf and 800 Lf groups was lower than the control value. Moreover, malondialdehyde concentration in the liver of Asian sea bass was increased with increasing the dietary Lf supplementation. The results of the study suggest that supplementing diet with 800 mg Lf kg⁻¹ stimulates non-specific immune response in Asian sea bass. Nonetheless, selecting an appropriate dose can be difficult, especially since both the higher and the lower dose tested may result in adverse effects.

本研究的目的是评估乳铁蛋白 (Lf) 对亚洲鲈鱼 ( Lates calcarifer )生长和摄食性能、生化和免疫参数的影响。基础日粮补充了 0（对照）、400（400 Lf）或 800（800 Lf）mg Lf kg ^-1日粮。结果表明，当饮食中添加 800 mg Lf kg ^-1时，先天免疫参数显着增加. 800 Lf组血清白蛋白值最高，血糖浓度最低。400 Lf和800 Lf组的肝过氧化氢酶活性低于对照值。此外，亚洲鲈鱼肝脏中的丙二醛浓度随着膳食 Lf 补充剂的增加而增加。研究结果表明，在亚洲鲈鱼中添加 800 mg Lf kg ^{-1 可}刺激非特异性免疫反应。尽管如此，选择合适的剂量可能很困难，特别是因为测试的较高和较低剂量都可能导致不良反应。