Background

Personal glucose meters, primarily designed for self-control of glucose concentration in patients with diabetes, are frequently used in clinical practice as point-of-care equipment. The procedure of washing hands with water and soap before testing, as recommended by the manufacturer of personal glucose meters, in hospital wards is often difficult to fulfil and is replaced by disinfecting the place of blood sampling with isopropyl alcohol.

Aim

The purpose of the research was to evaluate the effect of different disinfecting procedures on glycemia measurement in capillary blood using personal glucose meters.

Materials and methods

Four measurements of glycemia were taken in each of 50-volunteer group using Accu-Check Performa (Roche, Swiss) glucose meter using different procedures: washing hands with soap and drying them (1), disinfection with isopropyl alcohol and waiting for the disinfectant to evaporate (2) and the immediate puncture after disinfection. In the latter case two kind of single-use lancets were use – typical for adult (3) and smaller preferred by diabetics or children (4).

Results

Paired T-student test showed no statistically significant difference between measurements 1st and 2nd 95% CI (−4.282 to 0.322), p = 0.09. However, the comparison between 1st/3rd and 1st/4th showed statistically significant difference, 95% CI (−4.964 to −0.796), p = 0,0077 (p < 0,01) and 95% CI (−7.842 to −2.917), p = 0.00006 (p < 0.001).

Conclusions

The procedure of disinfection when fluid completely evaporates has no effect on glucose measurements. Sampling the wet finger influences results of glucose measurement but observed changes were clinically irrelevant.

中文翻译：

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使用个人血糖仪消毒程序对葡萄糖浓度的影响

背景

个人血糖仪主要用于糖尿病患者自我控制血糖浓度，在临床实践中经常用作即时护理设备。在医院病房，按照个人血糖仪制造商的建议，在测试前用水和肥皂洗手的程序通常难以实现，取而代之的是用异丙醇对采血场所进行消毒。

目的

该研究的目的是评估不同消毒程序对使用个人血糖仪测量毛细血管血中血糖的影响。

材料和方法

使用 Accu-Check Performa（Roche，瑞士）血糖仪，使用不同的程序对 50 名志愿者的每个组进行四次血糖测量：用肥皂洗手并擦干 (1)、用异丙醇消毒并等待消毒剂消毒。蒸发（2）消毒后立即穿刺。在后一种情况下，使用了两种一次性使用的刺血针——典型用于成人 (3) 和更小的糖尿病患者或儿童首选 (4)。

结果

配对 T-student 测试显示第一次和第二次 95% CI（-4.282 至 0.322）之间的测量结果没有统计学上的显着差异，p = 0.09。然而，第 1/3 次和第 1/4 次之间的比较显示出统计学上的显着差异，95% CI（-4.964 至 -0.796），p = 0.0077（p < 0.01）和 95% CI（-7.842 至 -2.917 ), p = 0.00006 (p < 0.001)。

结论

流体完全蒸发时的消毒程序对葡萄糖测量没有影响。对湿手指进行采样会影响葡萄糖测量的结果，但观察到的变化与临床无关。