Seminars in Respiratory and Critical Care Medicine ( IF 2.3 ) Pub Date : 2021-05-24 , DOI: 10.1055/s-0041-1729173 Cassie C Kennedy 1, 2 , Kelly M Pennington 1, 2 , Elena Beam 2, 3 , Raymund R Razonable 2, 3
Invasive fungal infections threaten lung transplant outcomes with high associated morbidity and mortality. Pharmacologic prophylaxis may be key to prevent posttransplant invasive fungal infections, but cost, adverse effects, and absorption issues are barriers to effective prophylaxis. Trends in fungal infection diagnostic strategies utilize molecular diagnostic methodologies to complement traditional histopathology and culture techniques. While lung transplant recipients are susceptible to a variety of fungal pathogens, Candida spp. and Aspergillus spp. infections remain the most common. With emerging resistant organisms and multiple novel antifungal agents in the research pipeline, it is likely that treatment strategies will continue to evolve.
中文翻译:
肺移植中的真菌感染
侵袭性真菌感染威胁着肺移植的结果,相关的发病率和死亡率很高。药物预防可能是预防移植后侵袭性真菌感染的关键,但成本、副作用和吸收问题是有效预防的障碍。真菌感染诊断策略的趋势利用分子诊断方法来补充传统的组织病理学和培养技术。虽然肺移植受者对多种真菌病原体敏感,但念珠菌属。和曲霉属。感染仍然是最常见的。随着研究管道中出现抗药性生物和多种新型抗真菌剂,治疗策略可能会继续发展。