Purpose

This large cross-sectional population-based study investigated the relationship between dry eye disease (DED) and health-related quality of life (HR-QoL).

Methods

Dry eye and HR-QoL were assessed in 78,165 participants (19–94 yrs, 59.2% female) from the Dutch population-based Lifelines cohort, using the WHS and the SF36 questionnaire, respectively. Logistic regression was used to assess the relationship between DED and below median Physical Component Summary (PCS) and Mental Component Summary (MCS) score, corrected for age, sex, education, BMI, and 52 comorbidities.

Results

Overall, 8.9% of participants had DED. Participants with DED had an increased risk of low PCS (OR 1.54 (95% CI 1.46–1.62)) and MCS scores (OR 1.39 (95% CI 1.32–1.46)), corrected for age and sex. This risk remained significant after correction for comorbidities (P < 0.0005). Increasing DED symptom frequency was associated with decreasing HR-QoL (P < 0.0005). Undiagnosed DED subjects had a significantly increased risk of low mental HR-QoL with increasing dry eye symptoms compared to diagnosed subjects (P < 0.0005). Compared to allergic conjunctivitis, glaucoma, macular degeneration and retinal detachment, DED showed the highest risk of low HR-QoL. Compared to other common systemic and chronic disorders, such as depression, rheumatoid arthritis, and COPD, DED was distinctive by having a substantial reduction in both PCS and MCS.

Conclusion

DED is associated with substantial reductions in both physical and mental HR-QoL, also after correction for associated comorbidities. Not having a diagnosis is associated with worse mental HR-QoL in subjects with severe DED. Our results underline the importance of recognizing dry eye as a serious disorder.

中文翻译：

---

干眼病的身心负担：一项基于人群的大型研究，调查与健康相关的生活质量及其决定因素的关系

目的

这项基于人群的大型横断面研究调查了干眼病 (DED) 与健康相关生活质量 (HR-QoL) 之间的关系。

方法

分别使用 WHS 和 SF36 问卷对来自荷兰基于人群的生命线队列的 78,165 名参与者（19-94 岁，59.2% 女性）的干眼和 HR-QoL 进行了评估。Logistic 回归用于评估 DED 与低于中位数的身体成分总结 (PCS) 和精神成分总结 (MCS) 得分之间的关​​系，并针对年龄、性别、教育、BMI 和 52 种合并症进行校正。

结果

总体而言，8.9% 的参与者患有 DED。DED 参与者发生低 PCS（OR 1.54（95% CI 1.46–1.62））和 MCS 评分（OR 1.39（95% CI 1.32–1.46））的风险增加，经年龄和性别校正。在校正合并症后，这种风险仍然显着（P < 0.0005）。增加 DED 症状频率与降低 HR-QoL 相关（P < 0.0005）。与诊断的受试者相比，未确诊的 DED 受试者的精神 HR-QoL 低风险显着增加，干眼症状增加（P < 0.0005）。与过敏性结膜炎、青光眼、黄斑变性和视网膜脱离相比，DED 显示低 HR-QoL 的风险最高。与其他常见的全身性和慢性疾病（如抑郁症、类风湿性关节炎和 COPD）相比，DED 的独特之处在于 PCS 和 MCS 均显着减少。

结论

DED 与身体和精神 HR-QoL 的显着降低有关，在纠正相关合并症后也是如此。在患有严重 DED 的受试者中，没有诊断与较差的心理 HR-QoL 相关。我们的结果强调了将干眼症识别为严重疾病的重要性。