Graphene is a widely used material as a therapeutic agent (drug) carrier due to its low toxicity, high surface area, specific flake-shape, 2-dimensional structure and geometry. In order to evaluate the efficiency of drug delivery improved by using graphene oxide as a drug carrier, drug release experiment using Cytochrome-C (Cyto- C), a model drug, was carried out. First of all, different ratios of Cyto-C were combined with 100 mg GO to investigate the best drug-loading efficiency so that the best loading ratio was confirmed with Cyto-C:GO of 1:2. Alginate hydrogel (Alg hydrogel) and Alginate-Graphene oxide hydrogel (Alg-GO hydrogel) were fabricated by cross-linking in 0.1 M CaCl₂ solution. Characterization of the hydrogels was confirmed by Fourier transform infrared (FT-IR) and scanning electron microscope (SEM) analysis. The drug efficiency by the ratio of graphene oxide to Cyto-C was compared by ultraviolet visible spectrophotometer (UV-VIS). The difference in drug release behavior in hydrogels was confrimed by drug release test. The Alg-GO hydrogel exhibited slow and steady release compared to that of alginate hydrogel as control. In this study, we demonstrated that applying graphene oxide as a drug carrier affects in control of drug release behavior.

石墨烯由于其低毒性，高表面积，特定的薄片形状，二维结构和几何形状而被广泛用作治疗剂（药物）载体。为了评估通过使用氧化石墨烯作为药物载体改善的药物递送效率，进行了使用模型药物Cytochrome-C（Cyto-C）进行药物释放实验。首先，将不同比例的Cyto-C与100 mg GO组合以研究最佳载药率，从而以1：2的Cyto-C：GO确认最佳载药率。通过在0.1 M CaCl _2中交联来制备藻酸盐水凝胶（Alg水凝胶）和藻酸盐石墨烯氧化物水凝胶（Alg-GO水凝胶）。解决方案。通过傅里叶变换红外（FT-IR）和扫描电子显微镜（SEM）分析确认了水凝胶的表征。通过紫外可见分光光度计（UV-VIS）比较了氧化石墨烯与Cyto-C之比的药物效率。水凝胶中药物释放行为的差异通过药物释放测试来确认。与作为对照的藻酸盐水凝胶相比，Alg-GO水凝胶显示出缓慢而稳定的释放。在这项研究中，我们证明了应用氧化石墨烯作为药物载体会影响药物释放行为的控制。