Abstract

Two previously undescribed dibenzocyclooctadiene lignans, named sieverlignans D–E (1–2), as well as eight known ones (3–10), were isolated from the aerial parts of Artemisia sieversiana. Their structures were elucidated from extensive spectroscopic analysis, including HRMS, NMR and electronic circular dichroism (ECD) experiments. This study is the first to report dibenzocyclooctadiene lignans in the genus Artemisia and this plant. All the compounds were evaluated for their anti-neuroinflammatory activities on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compounds 1 and 6 exhibited the moderate activities with their IC₅₀ values of 47.7 and 21.9 μM, compared to a positive control quercetin with the IC₅₀ value of 16.0 μM.

Graphic abstract

中文翻译：

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来自艾蒿的二苯并环辛二烯木脂素及其抗炎活性

摘要

两个以前未描述dibenzocyclooctadiene木脂素，命名为sieverlignans d-E（1 - 2） ，以及8级公知的（3 - 10） ，从地上部分分离蒿碱地肤。它们的结构是通过广泛的光谱分析阐明的，包括 HRMS、NMR 和电子圆二色性 (ECD) 实验。该研究首次报道了蒿属和该植物中的二苯并环辛二烯木脂素。评估了所有化合物对 BV-2 鼠小胶质细胞中脂多糖 (LPS) 诱导的一氧化氮产生的抗神经炎症活性。化合物1和6与 IC ₅₀值为 16.0 μM的阳性对照槲皮素相比，槲皮素表现出中等活性，其 IC ₅₀值为 47.7 和 21.9 μM。

图形摘要