Coronary artery disease (CAD) is one of the most prevalent diseases around the world; however, finding the best noninvasive, low-cost, and more easily accessible test for its screening has been a challenge for several years. Eighty-nine patients suspected of stable CAD underwent 2D-speckle-tracking echocardiography (2DSTE) at resting position and offline longitudinal myocardial strain analysis, followed by coronary angiography. The correlation of the global longitudinal strain (GLS) and territorial longitudinal strain (TLS) with significant CAD (70% and more stenosis in at least one coronary artery) was then evaluated. The statistical analysis showed a significant correlation between low GLS and significant CAD (P=0.0001). The results also showed a significant correlation between low TLS and significant CAD in the left and right coronary artery territories. The optimal cut-off point of GLS for the detection of significant CAD was −19.25, with a sensitivity of 76.5% and specificity of 76.6%. This study confirmed the usefulness of 2DSTE myocardial strain analysis in diagnosis of CAD for detecting the affected coronary arteries using GLS and SLS.

中文翻译：

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心肌张力分析作为无创性筛查试验，用于诊断稳定的冠状动脉疾病

冠状动脉疾病（CAD）是世界上最流行的疾病之一；然而，寻找最好的非侵入性，低成本且更容易获得的筛查方法多年来一直是一项挑战。89名疑似CAD稳定的患者在静止位置进行了2D斑点跟踪超声心动图（2DSTE），并进行了离线纵向心肌应变分析，然后进行了冠状动脉造影。然后评估总体纵向应变（GLS）和领土纵向应变（TLS）与显着CAD（至少一根冠状动脉狭窄70％和更多狭窄）的相关性。统计分析表明，低GLS与显着CAD之间存在显着相关性（P = 0.0001）。结果还显示，左冠状动脉和右冠状动脉区域的低TLS和显着的CAD之间存在显着相关性。用于检测显着CAD的GLS的最佳分界点是-19.25，灵敏度为76.5％，特异性为76.6％。这项研究证实了2DSTE心肌应变分析在诊断CAD中使用GLS和SLS检测受影响的冠状动脉方面的有用性。