Pain Intensity and Pain Interference in People With Progressive Multiple Sclerosis Compared With People With Relapsing-Remitting Multiple Sclerosis,Archives of Physical Medicine and Rehabilitation

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Pain Intensity and Pain Interference in People With Progressive Multiple Sclerosis Compared With People With Relapsing-Remitting Multiple Sclerosis
Archives of Physical Medicine and Rehabilitation ( IF 4.3 ) Pub Date : 2021-05-25 , DOI: 10.1016/j.apmr.2021.05.003
Lindsey M Knowles ₁ , Kala M Phillips ₂ , Tracy E Herring ₂ , Kevin N Alschuler ₃ , Mark P Jensen ₂ , Aaron P Turner ₁ , Dawn M Ehde ₂

Affiliation

Objective

To describe pain intensity and interference in people with progressive multiple sclerosis (MS), compare these with people with relapsing-remitting multiple sclerosis (RRMS), and identify common and unique factors associated with pain intensity in people with progressive MS and RRMS.

Design

Observational, cross-sectional analysis using baseline data from a longitudinal survey on quality of life in participants with MS.

Setting

Community.

Participants

A total of 573 adults with MS (N=573; progressive MS, n=142; RRMS, n=431).

Interventions

Not applicable.

Main Outcome Measures

Average pain intensity was measured by an 11-point numeric rating scale, and pain interference was measured by the Patient-Reported Outcomes Measurement Information System Pain Interference Short Form.

Results

Participants with progressive MS reported moderate average pain intensity (3.22±2.50) and elevated pain interference (T score of 55.55±9.13). They did not differ significantly from those with RRMS in average pain intensity or pain interference. Common factors associated with higher average pain intensity were more severe disability, lower education level, unemployment, and current smoking. In those with progressive MS, older age was associated with lower average pain intensity.

Conclusions

Pain intensity and interference are similar across MS types. In addition to assessing and treating pain, it is important to screen for modifiable pain-related factors, such as smoking cessation, in this population.

中文翻译：

与复发缓解型多发性硬化症患者相比，进行性多发性硬化症患者的疼痛强度和疼痛干扰

客观的

为了描述进行性多发性硬化症 (MS) 患者的疼痛强度和干扰，将这些与复发缓解型多发性硬化症 (RRMS) 患者进行比较，并确定与进行性多发性硬化症和 RRMS 患者疼痛强度相关的常见和独特因素。

设计

使用来自 MS 参与者生活质量纵向调查的基线数据进行观察性横断面分析。

环境

社区。

参与者

共有 573 名成人 MS（N=573；进展型 MS，n=142；RRMS，n=431）。

干预措施

不适用。

主要观察指标

平均疼痛强度由 11 点数字评定量表测量，疼痛干扰由患者报告结果测量信息系统疼痛干扰简表测量。

结果

患有进行性 MS 的参与者报告了中等平均疼痛强度 (3.22±2.50) 和升高的疼痛干扰 (T 评分为 55.55±9.13)。他们在平均疼痛强度或疼痛干扰方面与 RRMS 患者没有显着差异。与较高平均疼痛强度相关的常见因素是更严重的残疾、较低的教育水平、失业和目前吸烟。在进行性 MS 患者中，年龄越大平均疼痛强度越低。