A 14-year-old girl is seen in an outpatient clinic with a new diagnosis of migraine without aura. She is having at least one episode every week and it is affecting her time in school. Her father has read online that regular high-dose magnesium supplements may be helpful to reduce frequency of migraine. This is not included in local or national guidance, so you decide to research the evidence for benefit. In adolescents (10–18 years) with migraine, with or without aura (population), is the use of high-dose magnesium supplementation (intervention) helpful in reducing the frequency and severity of episodes (outcome)? MEDLINE via PubMed for primary and secondary sources up to October 2020 using the search terms ‘(magnesium) AND (migraine) AND (adolescent OR teenage OR young OR paediatric)’. Sixty-four results were found, many of which only included an adult population (>18 years of age). Nine papers were considered in detail, and four included (table 1).1 View this table: Table 1 Summary of included studies The International Headache Society (IHS) defines migraine as ‘a recurrent headache that occurs with or without aura and lasts for 2–48 hours.’ It is a typical presentation in young people and is in the top five most prevalent long-term conditions in children.2 The onset of migraine tends to last between 15 and 30 min, occurring unilaterally. Exacerbated by physical exercise, its accompanying features include phonophobia, photophobia, vomiting and nausea.2 Patients often describe the headache as …

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高剂量镁补充剂对青少年偏头痛有帮助吗？

一名 14 岁的女孩在门诊就诊，新诊断为无先兆偏头痛。她每周至少发生一集，这影响了她在学校的时间。她的父亲在网上读到，定期服用高剂量镁补充剂可能有助于减少偏头痛的发生频率。这不包括在地方或国家指南中，因此您决定研究证据以获得好处。对于有或没有先兆（人群）偏头痛的青少年（10-18 岁），使用高剂量镁补充剂（干预）是否有助于降低发作频率和严重程度（结果）？MEDLINE 通过 PubMed 使用搜索词“（镁）AND（偏头痛）AND（青少年或青少年或年轻或儿科）”获取主要和次要资源，直至 2020 年 10 月。找到了六十四个结果，其中许多仅包括成年人口（> 18 岁）。详细考虑了 9 篇论文，其中包括 4 篇（表 1）。1 查看此表：表 1 纳入研究摘要 国际头痛协会 (IHS) 将偏头痛定义为“有或无先兆发生并持续 2 年的复发性头痛-48小时。' 这是年轻人的典型表现，是儿童最常见的前五名长期病症。2 偏头痛的发作往往持续 15 到 30 分钟，单侧发生。因体育锻炼而加剧，其伴随的特征包括畏声、畏光、呕吐和恶心。 2 患者通常将头痛描述为…… 表 1 纳入研究总结 国际头痛协会 (IHS) 将偏头痛定义为“有或无先兆发生并持续 2-48 小时的复发性头痛”。这是年轻人的典型表现，是儿童最常见的前五名长期病症。2 偏头痛的发作往往持续 15 到 30 分钟，单侧发生。因体育锻炼而加剧，其伴随的特征包括畏声、畏光、呕吐和恶心。 2 患者通常将头痛描述为…… 表 1 纳入研究总结 国际头痛协会 (IHS) 将偏头痛定义为“有或无先兆发生并持续 2-48 小时的复发性头痛”。这是年轻人的典型表现，是儿童最常见的前五名长期病症。2 偏头痛的发作往往持续 15 到 30 分钟，单侧发生。因体育锻炼而加剧，其伴随的特征包括畏声、畏光、呕吐和恶心。 2 患者通常将头痛描述为…… 单方面发生。因体育锻炼而加剧，其伴随的特征包括畏声、畏光、呕吐和恶心。 2 患者通常将头痛描述为…… 单方面发生。因体育锻炼而加剧，其伴随的特征包括畏声、畏光、呕吐和恶心。 2 患者通常将头痛描述为……