Role of maternal tryptophan metabolism in allergic diseases in the offspring,Clinical & Experimental Allergy

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Role of maternal tryptophan metabolism in allergic diseases in the offspring
Clinical & Experimental Allergy ( IF 6.3 ) Pub Date : 2021-05-25 , DOI: 10.1111/cea.13953
Hui Xing Lau ₁ , Sarah El-Heis ₂ , Qai Ven Yap ₃ , Yiong Huak Chan ₃ , Cheryl Pei Ting Tan ₄ , Neerja Karnani ₁ , Karen Mei Ling Tan ₁ , Elizabeth Huiwen Tham _{1,

4,

5} , Anne Eng Neo Goh ₆ , Oon Hoe Teoh ₇ , Kok Hian Tan ₈ , Johan Gunnar Eriksson _{1,

9,

10,

11} , Yap Seng Chong _{1,

9} , Mary Foong-Fong Chong _{1,

12} , Hugo Van Bever _{4,

5} , Bee Wah Lee ₄ , Lynette P Shek ₄ , Keith M Godfrey ₁₃ , Evelyn Xiu Ling Loo _{1,

4}

Affiliation

Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore City, Singapore.
Medical Research Council Lifecourse Epidemiology Unit, Southampton, UK.
Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.
Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore City, Singapore.
Allergy Service, Department of Paediatrics, KK Women's and Children's Hospital (KKWCH), Singapore City, Singapore.
Respiratory Service, Department of Paediatrics, KK Women's and Children's Hospital (KKWCH), Singapore City, Singapore.
Department of Maternal Fetal Medicine, KK Women's and Children's Hospital (KKWCH), Singapore City, Singapore.
Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore City, Singapore.
Folkhälsan Research Center, Helsinki, Finland.
Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore City, Singapore.
NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Nicotinamide (vitamin B3) is a metabolite of tryptophan and dietary precursor of enzymes involved in many regulatory processes, which may influence fetal immune development.

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