Evidence on the effects of meat consumption from different sources on the risk of bladder cancer (BC) is limited and controversial. Therefore, this study aimed to evaluate the associations between meat consumption and BC risk using a pooled data approach. Individual data from 11 prospective cohorts comprising 2848 BC cases and 515,697 non-cases with a total of 5,498,025 person-years of follow-up was pooled and analysed to investigate the potential associations between total red meat and products, red meat, processed meat, poultry and total fish and BC risk. Hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were estimated using Cox regression models stratified on cohort. Overall, an increased BC risk was found for high intake of organ meat (HR comparing highest with lowest tertile: 1.18, 95% CI: 1.03, 1.36, p-trend = 0.03). On the contrary, a marginally inverse association was observed for total fish intake and BC risk among men (HR comparing highest with lowest tertile: 0.79, 95% CI 0.65, 0.97, p-trend = 0.04). No associations were observed for other meat sources. Results of this prospective study suggest that organ meat consumption may be associated with BC development. Replication in large-scale prospective studies and investigation of possible causal mechanisms is needed.

关于不同来源的肉类消费对膀胱癌 (BC) 风险影响的证据有限且存在争议。因此，本研究旨在使用汇总数据方法评估肉类消费与 BC 风险之间的关联。汇总和分析来自 11 个前瞻性队列的个人数据，包括 2848 名 BC 病例和 515,697 名非病例，总共 5,498,025 人年的随访，以调查总红肉与产品、红肉、加工肉类、家禽之间的潜在关联和总鱼类和 BC 风险。使用按队列分层的 Cox 回归模型估计风险比 (HR) 和相应的 95% 置信区间 (CI)。总体而言，发现高摄入内脏肉会增加 BC 风险（HR 最高与最低三分位数比较：1.18, 95% CI：1.03, 1.36，p 趋势 = 0.03）。相反，在男性中观察到总鱼类摄入量和 BC 风险呈略微负相关（HR 最高与最低三分位数比较：0.79, 95% CI 0.65, 0.97, p 趋势 = 0.04）。没有观察到其他肉类来源的关联。这项前瞻性研究的结果表明，内脏肉的摄入可能与 BC 的发展有关。需要在大规模前瞻性研究中进行复制并调查可能的因果机制。