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Serum albumin is a predictor of respiratory hospitalization in patients with bronchiectasis
Chronic Respiratory Disease ( IF 3.5 ) Pub Date : 2021-05-25 , DOI: 10.1177/14799731211017548
Sunmi Ju 1 , Jong Hwan Jeong 1 , Manbong Heo 1 , I Re Heo 2 , Tae Hoon Kim 2 , Ho Cheol Kim 2 , Jung-Wan Yoo 1 , Yu Ji Cho 1 , Yi Yeong Jeong 1 , Jong Deog Lee 1 , Seung Jun Lee 1
Affiliation  

We evaluated serum albumin as an index for predicting respiratory hospitalization in patients with bronchiectasis. We retrospectively reviewed the medical records of 177 patients with bronchiectasis, categorized them into low and normal albumin groups, and compared their clinical characteristics. The prediction of respiratory hospitalization by factors such as serum albumin level, bronchiectasis severity index (BSI), and FACED score (an acronym derived from five variables of forced expiratory volume in 1 s; FEV1, age, chronic colonization of Pseudomonas aeruginosa, extent of bronchiectasis, and dyspnea) was assessed. There were 15 and 162 patients categorized in the low and normal albumin groups, respectively. The low albumin group had lower body mass index and forced expiratory volume in 1 s, and higher age, frequency of previous respiratory hospitalization, percentage of Pseudomonas colonization, number of affected lobes, BSI and FACED scores, and C-reactive protein (CRP) level, than the normal albumin group. The areas under the receiver operating characteristic curve of serum albumin level and BSI and FACED scores for predicting respiratory hospitalization were 0.732 (95% confidence interval (CI), 0.647–0.816), 0.873 (95% CI, 0.817–0.928), and 0.708 (95% CI, 0.618–0.799), respectively. Albumin level, CRP, modified Medical Research Council score, and chronic Pseudomonas aeruginosa (and other organisms) colonization were independent risk factors for respiratory hospitalization. Low serum albumin level was associated with worse clinical condition, higher severity scores, and respiratory hospitalization in patients with bronchiectasis.



中文翻译:

血清白蛋白是支气管扩张患者呼吸系统住院的预测指标

我们评估了血清白蛋白作为预测支气管扩张患者呼吸系统住院治疗的指标。我们回顾性回顾了177例支气管扩张患者的病历,将他们分为低白蛋白组和正常白蛋白组,并比较了他们的临床特征。通过血清白蛋白水平、支气管扩张严重程度指数 (BSI) 和 FACED 评分(来自 1 s 用力呼气量的五个变量的首字母缩写词;FEV 1、年龄、铜绿假单胞菌的慢性定植)等因素预测呼吸系统住院、支气管扩张的程度和呼吸困难)进行了评估。分别有 15 名和 162 名患者分为低白蛋白组和正常白蛋白组。低白蛋白组的体重指数和 1 s 用力呼气量较低,年龄、既往呼吸道住院频率、假单胞菌定植百分比、受影响的肺叶数量、BSI 和 FACED 评分以及 C 反应蛋白 (CRP)较高水平,高于正常白蛋白组。预测呼吸道住院治疗的血清白蛋白水平和 BSI 和 FACED 评分的受试者工作特征曲线下面积为 0.732(95% 置信区间(CI),0.647-0.816)、0.873(95% CI,0.817-0.928)和 0.708 (95% CI, 0.618–0.799),分别。白蛋白水平、CRP、修正的医学研究委员会评分和慢性铜绿假单胞菌(和其他生物)定植是呼吸道住院的独立危险因素。支气管扩张患者的低血清白蛋白水平与更差的临床状况、更高的严重程度评分和呼吸系统住院有关。

更新日期:2021-05-25
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