Background:

Few studies have jointly estimated incidence of MCI, conversion to probable dementia, and mortality in a nationally representatie sample.

Methods:

We used data from six waves of the National Health and Aging Trends Study (2011-2016). Multivariable-adjusted multi-state survival models (MSMs) were used to model incidence upon accounting for misclassification.

Results:

A total of 6,078 eligible NHATS participants were included (average age: 77.49 ± 7.79 years; 58.42% females; 68.99% non-Hispanic white). The incidence of MCI was estimated to be 41.0 [35.5, 47.3]/1,000 person-years (PY). Participants converted to probable dementia at a high rate of 241.3 [189.6, 307.0]/1,000 PY, though a small number also reverted from MCI to cognitively normal. Education was associated with lower incidence of MCI and conversion to probable dementia, but increased mortality in those with MCI. There were also substantial racial and ethnic disparities in the incidence of MCI and dementia.

Conclusions:

Our results underscore the relatively common incidence of and conversions between MCI and dementia in community-dwelling older Americans and uncover the beneficial impact of education to withstand cognitive impairment before death.

中文翻译：

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轻度认知障碍的发生率、可能转为痴呆症的发生率以及死亡率

 背景：

很少有研究在全国代表性样本中联合估计 MCI 的发病率、可能的痴呆症的转化率和死亡率。

 方法：

我们使用了六波国家健康和老龄化趋势研究（2011-2016）的数据。多变量调整多状态生存模型（MSM）用于根据错误分类对发生率进行建模。

 结果：

总共纳入了 6,078 名符合资格的 NHATS 参与者（平均年龄：77.49 ± 7.79 岁；58.42% 为女性；68.99% 非西班牙裔白人）。 MCI 的发病率估计为 41.0 [35.5, 47.3]/1,000 人年 (PY)。参与者以 241.3 [189.6, 307.0]/1,000 PY 的高比率转变为可能的痴呆症，尽管少数人也从 MCI 恢复到认知正常。教育与较低的 MCI 发病率和可能的痴呆症转化率相关，但会增加 MCI 患者的死亡率。 MCI 和痴呆症的发病率也存在显着的种族和民族差异。

 结论：

我们的研究结果强调了居住在社区的美国老年人中相对常见的 MCI 和痴呆症的发病率以及两者之间的转化，并揭示了教育对于在死前抵抗认知障碍的有益影响。