New trends in the development of multifunctional peptides to functionalize biomaterials,Journal of Peptide Science

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New trends in the development of multifunctional peptides to functionalize biomaterials
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2021-05-24 , DOI: 10.1002/psc.3335
Lluís Oliver-Cervelló _{1,

2} , Helena Martin-Gómez _{1,

2} , Carlos Mas-Moruno _{1,

2}

Affiliation

Improving cell-material interactions is a major goal in tissue engineering. In this regard, functionalization of biomaterials with cell instructive molecules from the extracellular matrix stands out as a powerful strategy to enhance their bioactivity and achieve optimal tissue integration. However, current functionalization strategies, like the use of native full-length proteins, are associated with drawbacks, thus urging the need of developing new methodologies. In this regard, the use of synthetic peptides encompassing specific bioactive regions of proteins represents a promising alternative. In particular, the combination of peptide sequences with complementary or synergistic effects makes it possible to address more than one biological target at the biomaterial surface. In this review, an overview of the main strategies using peptides to install multifunctionality on biomaterials is presented, mostly focusing on the combination of the RGD motif with other peptides sequences. The evolution of these approaches, starting from simple methods, like using peptide mixtures, to more advanced systems of peptide presentation, with very well defined chemical properties, are explained. For each system of peptide's presentation, three main aspects of multifunctionality—improving receptor selectivity, mimicking the extracellular matrix and preventing bacterial colonization while improving cell adhesion—are highlighted.

中文翻译：

多功能多肽功能化生物材料发展的新趋势

改善细胞与材料的相互作用是组织工程的主要目标。在这方面，使用来自细胞外基质的细胞指导性分子对生物材料进行功能化是增强其生物活性和实现最佳组织整合的有力策略。然而，目前的功能化策略，如使用天然全长蛋白质，存在缺陷，因此迫切需要开发新的方法。在这方面，使用包含蛋白质特定生物活性区域的合成肽代表了一种有前途的替代方案。特别地，具有互补或协同效应的肽序列的组合使得有可能在生物材料表面处理一个以上的生物靶标。在本次审查中，概述了使用肽在生物材料上安装多功能性的主要策略，主要关注 RGD 基序与其他肽序列的组合。解释了这些方法的演变，从简单的方法（如使用肽混合物）到更先进的肽呈递系统，具有非常明确的化学性质。对于肽呈现的每个系统，都强调了多功能性的三个主要方面——提高受体选择性、模拟细胞外基质和防止细菌定植，同时提高细胞粘附性。解释了使用肽混合物，更先进的肽呈递系统，具有非常明确的化学特性。对于肽呈现的每个系统，都强调了多功能性的三个主要方面——提高受体选择性、模拟细胞外基质和防止细菌定植，同时提高细胞粘附性。解释了使用肽混合物，更先进的肽呈递系统，具有非常明确的化学特性。对于肽呈现的每个系统，都强调了多功能性的三个主要方面——提高受体选择性、模拟细胞外基质和防止细菌定植，同时提高细胞粘附性。

更新日期：2021-05-24

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