Axonal injury is a key player of disability in persons with multiple sclerosis (pwMS). Yet, detecting and measuring it in vivo is challenging. The neurite orientation dispersion and density imaging (NODDI) proposes a novel framework for probing axonal integrity in vivo. NODDI at 3.0 Tesla was used to quantify tissue damage in pwMS and its relationship with disease progression.

中文翻译：

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在多发性硬化症中使用 MR 神经突方向分散和密度成像从地形学上评估脑损伤

轴突损伤是多发性硬化症 (pwMS) 患者致残的关键因素。然而，在体内检测和测量它具有挑战性。神经突定向分散和密度成像 (NODDI) 提出了一种用于探测体内轴突完整性的新框架。3.0 特斯拉的 NODDI 用于量化 pwMS 中的组织损伤及其与疾病进展的关系。