CagA+ Helicobacter pylori infection and N-nitrosodimethylamine administration induce cholangiocarcinoma development in hamsters,Helicobacter

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CagA+ Helicobacter pylori infection and N-nitrosodimethylamine administration induce cholangiocarcinoma development in hamsters
Helicobacter ( IF 4.3 ) Pub Date : 2021-05-24 , DOI: 10.1111/hel.12817
Rungtiwa Dangtakot _{1,

2} , Kitti Intuyod _{2,

3} , Yaovalux Chamgramol _{2,

3} , Chawalit Pairojkul _{2,

3} , Somchai Pinlaor _{2,

4} , Chanakan Jantawong _{1,

2} , Thatsanapong Pongking _{1,

2} , Ornuma Haonon ₅ , Ning Ma ₆ , Porntip Pinlaor _{2,

7}

Affiliation

Helicobacter pylori (HP) has been detected in the hepatobiliary tract of cholangiocarcinoma (CCA) patients in regions both endemic and non-endemic for Opisthorchis viverrini (OV) infection. However, whether H. pylori infection promotes CCA development remains unknown. We investigated CCA development in hamsters induced by a combination of infection with H. pylori and administration of N-nitrosodimethylamine (NDMA) and compared findings with those in an OV plus NDMA group.

中文翻译：

CagA+幽门螺杆菌感染和N-亚硝基二甲胺给药诱导仓鼠胆管癌的发展

已在胆管癌 (CCA) 患者的肝胆道中检测到幽门螺杆菌(HP)，这些患者位于Opisthorchis viverrini (OV) 感染的地方性和非地方性区域。然而，无论H . pylori感染促进 CCA 发展仍然未知。我们通过感染的组合引起的仓鼠调查CCA的发展^ h。pylori和N-亚硝基二甲胺(NDMA) 的给药，并将结果与 OV 加 NDMA 组的结果进行比较。

更新日期：2021-07-28

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