Super enhancer (SE) is a cluster of enhancers that has a stronger ability to promote transcription compared to the typical enhancer (TE). Similar to TE, which can transcribe enhancer RNA (eRNA), SE produces super enhancer RNA (seRNA). The activation of SE is cell and tissue-specific, and the SE-associated genes are mostly linked to the cell fate. This is demonstrated by the important role-played by SE in the embryonic stem cell (ESC) and multiple cancer development. SeRNA regulates transcription in both cis and trans configuration, and those located in the cytoplasm mediates various cell activities. However, the functions of seRNAs are unclear, and most of them have a synergistic effect with SE and SE-associated genes. In this mini review, we summarized the mechanisms of seRNA and functions of both SE and seRNA.

中文翻译：

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超级增强子RNA的机制和功能

超级增强子 (SE) 是一组增强子，与典型的增强子 (TE) 相比，其促进转录的能力更强。与可以转录增强子 RNA (eRNA) 的 TE 类似，SE 产生超级增强子 RNA (seRNA)。SE的激活是细胞和组织特异性的，SE相关基因大多与细胞命运有关。SE 在胚胎干细胞 (ESC) 和多种癌症发展中发挥的重要作用证明了这一点。SeRNA 调节顺式和反式转录结构，位于细胞质中的结构介导各种细胞活动。然而，seRNA的功能尚不清楚，它们大多与SE和SE相关基因具有协同作用。在这篇小型综述中，我们总结了 seRNA 的机制以及 SE 和 seRNA 的功能。