Aim

To determine if a gradual adaptation period is necessary for neophytes when fitted with modern hydrogel or silicone hydrogel reusable disposable contact lenses.

Method

Across four sites, 74 neophytes (18–28 years) were randomly assigned to a reusable lens cleaned nightly with Opti-Free® Puremoist® multi-purpose contact lens solution: Proclear® (hydrogel) or Biofinity® (silicone hydrogel) and an adaptation schedule: fast (10 h wear from the first day) or gradual (4 h on the first day, increasing their wear time by 2 h on each subsequent day until they had reached 10 h). Masked investigators graded ocular surface physiology and non-invasive tear breakup time (NIBUT) and a range of comfort, vision and lens handling subjective ratings (0–100 visual analogue scales) were recorded at the baseline visit and after 10 h of lens wear, 4–6 days and 12–14 days after lens fitting. Subjective scores were also repeated after 7 days.

Results

There was no difference (p > 0.05) in ocular surface physiology or NIBUT between fast and gradual adaptation groups at any time point in either lens type with the exception of increased corneal staining (p = 0.019) in the silicone hydrogel fast adaptation group after 4–6 days, but was similar by 12–14 days. Subjective scores were also similar across the visits and lens types with the exception of ‘lens awareness’ (p = 0.019) which was less in the gradual versus the fast adaptation silicone hydrogel lens group at 12–14 days.

Conclusion

There seems to be no clinical benefit for recommending a gradual adaptation period in new wearers fitted with modern soft reusable disposable contact lenses. The findings of this work add to a growing body of evidence suggesting that such advice is unnecessary in regular soft contact lens wear, which has important ramifications for the initial clinical management of these patients.

中文翻译：

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新手佩戴者每月快速适应软性隐形眼镜还是逐渐适应

目标

确定佩戴现代水凝胶或硅水凝胶可重复使用一次性隐形眼镜的新手是否需要逐渐适应期。

方法

在四个地点，74 名新手（18-28 岁）被随机分配到使用 Opti-Free® Puremoist® 多功能隐形眼镜溶液每晚清洁的可重复使用镜片：Proclear®（水凝胶）或 Biofinity®（硅水凝胶）和适应性时间表：快速（从第一天开始佩戴 10 小时）或渐进式（第一天佩戴 4 小时，随后每天将佩戴时间增加 2 小时，直到达到 10 小时）。蒙面研究人员在基线访问和镜片佩戴 10 小时后记录了眼表生理学和无创泪液破裂时间 (NIBUT) 以及一系列舒适度、视力和镜片处理主观评分（0-100 视觉模拟量表），配镜后 4-6 天和 12-14 天。主观评分也在 7 天后重复。

结果

在任何一种晶状体类型的任何时间点，快速和渐进适应组之间的眼表生理学或 NIBUT 均无差异 (p > 0.05)，但硅水凝胶快速适应组 4 后角膜染色增加 (p = 0.019) 除外–6 天，但相似的 12–14 天。除了“镜片意识”（p = 0.019）之外，在 12-14 天，逐渐适应硅水凝胶镜片组与快速适应硅水凝胶镜片组相比，主观评分也相似。

结论

建议在配戴现代软性可重复使用一次性隐形眼镜的新佩戴者中逐步适应期似乎没有临床益处。这项工作的发现增加了越来越多的证据表明，在定期佩戴软性隐形眼镜时不需要此类建议，这对这些患者的初始临床管理具有重要影响。