The actin cytoskeleton is important for maintaining mechanical homeostasis in adherent cells, largely through its regulation of adhesion and cortical tension. The LIM (Lin-11, Isl1, MEC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to mechanically stressed actin filaments, suggesting a novel and widely conserved mechanism of mechanosensing. This review summarizes the current state of knowledge of LIM protein mechanosensitivity.

中文翻译：

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细胞力学生物学中的 LIM 结构域蛋白

肌动蛋白细胞骨架对于维持贴壁细胞的机械稳态很重要，主要是通过其对粘附和皮质张力的调节。含有LIM ( L in-11, I sl1, M EC-3) 结构域的蛋白质参与了无数的细胞机械敏感途径。最近的工作发现 LIM 结构域与机械应力的肌动蛋白丝结合，这表明了一种新颖且广泛保守的机械传感机制。本综述总结了 LIM 蛋白机械敏感性的知识现状。