NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration,Cell Proliferation

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NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-05-24 , DOI: 10.1111/cpr.13057
Guang-Zhi Zhang _{1,

2,

3} , Ming-Qiang Liu _{1,

2,

3} , Hai-Wei Chen _{1,

2,

3} , Zuo-Long Wu _{1,

2,

3} , Yi-Cheng Gao _{1,

2,

3} , Zhan-Jun Ma _{1,

2,

3} , Xue-Gang He _{1,

2,

3} , Xue-Wen Kang _{1,

2,

3,

4}

Affiliation

Intervertebral disc degeneration (IDD) is a common clinical degenerative disease of the spine. A series of factors, such as inflammation, oxidative stress and mechanical stress, promote degradation of the extracellular matrix (ECM) of the intervertebral discs (IVD), leading to dysfunction and structural destruction of the IVD. Nuclear factor-κB (NF-κB) transcription factor has long been regarded as a pathogenic factor of IDD. Therefore, NF-κB may be an ideal therapeutic target for IDD. As NF-κB is a multifunctional functional transcription factor with roles in a variety of biological processes, a comprehensive understanding of the function and regulatory mechanism of NF-κB in IDD pathology will be useful for the development of targeted therapeutic strategies for IDD, which can prevent the progression of IDD and reduce potential risks. This review discusses the role of the NF-κB signalling pathway in the nucleus pulposus (NP) in the process of IDD to understand pathological NP degeneration further and provide potential therapeutic targets that may interfere with NF-κB signalling for IDD therapy.

中文翻译：

NF-κB信号通路在髓核细胞功能和椎间盘退变中的作用

椎间盘退变（IDD）是临床常见的脊柱退行性疾病。炎症、氧化应激和机械应激等一系列因素促进椎间盘（IVD）细胞外基质（ECM）降解，导致IVD功能障碍和结构破坏。核因子-κB（NF-κB）转录因子长期以来被认为是IDD的致病因素。因此，NF-κB可能是IDD的理想治疗靶点。由于NF-κB是一种多功能的功能转录因子，在多种生物过程中发挥作用，全面了解NF-κB在IDD病理中的功能和调控机制将有助于制定IDD的靶向治疗策略，预防 IDD 的进展并降低潜在风险。本文探讨髓核（NP）中NF-κB信号通路在IDD过程中的作用，以进一步了解NP的病理变性，并为IDD治疗提供可能干扰NF-κB信号的潜在治疗靶点。

更新日期：2021-07-02

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