ABSTRACT

Purpose:To compare the efficacy and safety of foveal and extrafoveal half-dose photodynamic therapy (HD-PDT) for chronic Central Serous Chorioretinopathy (cCSC). Methods: This retrospective, cohort study included cCSC eyes submitted to HD-PDT on foveal (F) or extrafoveal (E) areas. Patients were evaluated at baseline and 12 weeks after treatment for best corrected visual acuity (BCVA) and the following spectral-domain optical coherence tomography (SD-OCT) subfoveal parameters: central macular thickness (CMT), outer nuclear layer, external limiting membrane, ellipsoid zone, interdigitation zone, choroidal thickness and subretinal fluid (SRF). Results: F group comprised 33 eyes (47.1%) and E group comprised 37 eyes (52.9%). Both groups showed an improvement of BCVA after HD-PDT with no significant differences in final BCVA (p = .41). CMT and SRF showed a significant improvement after HD-PDT in both groups, but the rate of disruption of the external retinal layers remained stable. During follow-up, SD-OCT parameters and the rate of anatomical success showed no significant differences regarding the treatment location. No major sequelae were noticed. Conclusion: Foveal and extrafoveal applications of HD-PDT for cCSC showed comparable efficacy and safety.

摘要

目的：比较中央凹和中央凹外半剂量光动力疗法（HD-PDT）治疗慢性中央浆液性脉络膜视网膜病变（cCSC）的疗效和安全性。方法：这项回顾性队列研究包括在中央凹 (F) 或中央凹外 (E) 区域提交 HD-PDT 的 cCSC 眼睛。在基线和治疗后 12 周评估患者的最佳矫正视力 (BCVA) 和以下光谱域光学相干断层扫描 (SD-OCT) 中心凹下参数：中央黄斑厚度 (CMT)、外核层、外界膜、椭圆体区、叉指区、脉络膜厚度和视网膜下液 (SRF)。结果：F组33眼（47.1%），E组37眼（52.9%）。两组在 HD-PDT 后都显示出 BCVA 的改善，最终 BCVA 没有显着差异（p = .41)。两组在 HD-PDT 后 CMT 和 SRF 均有显着改善，但视网膜外层的破坏率保持稳定。在随访期间，SD-OCT 参数和解剖成功率在治疗位置方面没有显着差异。没有发现严重的后遗症。结论：HD-PDT 用于 cCSC 的中心凹和中心凹外应用显示出相当的疗效和安全性。