Inhibition of microRNA-129–2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1,Brain and Behavior

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Inhibition of microRNA-129–2-3p protects against refractory temporal lobe epilepsy by regulating GABRA1
Brain and Behavior ( IF 3.1 ) Pub Date : 2021-05-24 , DOI: 10.1002/brb3.2195
Guan-Yu Wang _{1,

2} , Zhi-Lin Luan _{1,

3} , Ning-Wei Che ₁ , De-Bin Yan _{1,

2} , Xiao-Wan Sun ₃ , Cong Zhang ₃ , Jian Yin _{1,

2}

Affiliation

Accumulating evidence demonstrates that certain microRNAs play critical roles in epileptogenesis. Our previous studies found microRNA (miR)-129–2-3p was induced in patients with refractory temporal lobe epilepsy (TLE). In this study, we aimed to explore the role of miR-129–2-3p in TLE pathogenesis.

中文翻译：

抑制 microRNA-129-2-3p 通过调节 GABRA1 预防难治性颞叶癫痫

越来越多的证据表明，某些 microRNA 在癫痫发生中起关键作用。我们之前的研究发现，难治性颞叶癫痫 (TLE) 患者可诱导 microRNA (miR)-129-2-3p。在本研究中，我们旨在探索 miR-129-2-3p 在 TLE 发病机制中的作用。

更新日期：2021-07-30

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