The ability of tissues and cells to move and rearrange is central to a broad range of diverse biological processes, comprising tissue remodeling and rearrangement in embryogenesis, cell migration in wound healing or cancer progression. These processes are linked to a solid-to-liquid transition, also known as unjamming transition, which enables tissues to switch between a stable state and an active, motile state. Various mechanisms, i.e. proliferation and motility, are key drivers for the (un)jamming transition on the cellular scale. However, beyond the scope of these fundamental mechanisms of cells, the biomolecular mechanism of (un)jamming is still unclear. In embryogenesis the proliferation rate of cells is high and the number density is continuously increasing, which indicates a number-density-driven jamming; whereas on the other hand during tumor progression cells have to unjam in tissues that are already densely packed, which suggests a shape-driven unjamming transition. Here we review recent studies on jamming transitions during embyrogenesis and cancer progression and pursue the question of how they might be interlinked. We discuss the role of density and shape during the jamming transition, and different biological factors driving it.

中文翻译：

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干扰胚胎发生和癌症进展

组织和细胞移动和重排的能力对于多种多样的生物学过程至关重要，包括胚胎发生中的组织重塑和重排，伤口愈合或癌症进展中的细胞迁移。这些过程与固体到液体的过渡（也称为脱干扰的过渡）有关，该过渡使组织能够在稳定状态和活动的运动状态之间切换。各种机制，即增殖和运动性，是细胞规模上（非）干扰过渡的关键驱动力。但是，除了这些基本的细胞机制之外，（未）干扰的生物分子机制仍然不清楚。在胚胎发生过程中，细胞的增殖速率很高，并且数量密度不断增加，这表明数量密度驱动的干扰。而另一方面，在肿瘤进展过程中，细胞必须在已经密集堆积的组织中解开阻塞，这表明形状驱动的解开干扰。在这里，我们回顾了关于在胚胎发生和癌症发展过程中干扰转化的最新研究，并探讨了它们如何相互联系的问题。我们讨论了在干扰过渡期间密度和形状的作用，以及驱动它的不同生物学因素。