当前位置: X-MOL 学术Emerging Mater. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Fabrication and characterization of bioactive nanoemulsion-based delivery systems
Emerging Materials Research ( IF 1.3 ) Pub Date : 2021-07-06 , DOI: 20.00280
Azime Yilmaz, Raciye Meral, Mohammad Kabli, Ertan Ermis, Perihan Kubra Akman, Enes Dertli, Osman Taylan, Osman Sagdic, Mustafa Tahsin Yilmaz

In this work, a nanoemulsion-based delivery system was developed by encapsulation of different concentrations (0.50%, 0.75% and 1.00% v/v) of oregano essential oil (OEO) within poly(vinyl alcohol). The delivery systems (OEO-loaded nanoemulsion systems (NESs)) were characterized in terms of size distribution, zeta potential and thermal, molecular, microstructural and antifungal properties. The average droplet diameter values were determined to be within the range 70–75 nm, while zeta potential values within the range 3.13–19.90 mV were recorded. An increase in the OEO concentration did not affect the size distribution of nanoemulsions. Change in the concentrations showed no visible differences in Fourier transform infrared spectra. However, for concentrations of 0.50, 0.75 and 1.00%, endothermic peak temperatures were recorded as 94, 105 and 117°C, respectively. The antifungal activity of NESs against the mycelial growth of Aspergillus niger was evaluated, revealing a significant enhancement in the antifungal activity in comparison with that of free OEO. The zone diameter of mycelial growth could be reduced by around 20, 55 and 65% using NESs at levels of 0.50, 0.75 and 1.00% v/v, respectively, over 6 days of incubation. The results of this study revealed the stronger antifungal efficiency of OEO by its encapsulation into NESs as compared with that of free OEO.

中文翻译:

基于生物活性纳米乳液的递送系统的制备和表征

在这项工作中,通过将不同浓度(0.50%、0.75% 和 1.00% v/v)的牛至精油 (OEO) 封装在聚乙烯醇中,开发了一种基于纳米乳液的递送系统。递送系统(载有OEO 的纳米乳液系统(NES))的特征在于尺寸分布、zeta 电位和热、分子、微观结构和抗真菌特性。平均液滴直径值被确定为在 70-75 nm 范围内,而 zeta 电位值在 3.13-19.90 mV 范围内被记录。OEO 浓度的增加不影响纳米乳液的尺寸分布。浓度的变化在傅立叶变换红外光谱中没有显示出可见的差异。然而,对于 0.50、0.75 和 1.00% 的浓度,吸热峰温度记录为 94、105 和 117°C,分别。NESs对菌丝体生长的抗真菌活性对黑曲霉进行了评估,发现与游离 OEO 相比,其抗真菌活性显着增强。在孵育 6 天后,分别使用 0.50、0.75 和 1.00% v/v 水平的 NES,菌丝体生长的区域直径可以减少约 20%、55% 和 65%。这项研究的结果表明,与游离的 OEO 相比,OEO 通过封装在 NES 中具有更强的抗真菌效率。
更新日期:2021-07-06
down
wechat
bug