Trigeminal nerve injury is known to cause severe persistent pain in the orofacial region. This pain is difficult to diagnose and treat. Recently, many animal studies have reported that rewiring of the peripheral and central nervous systems, non-neuronal cell activation, and up- and down-regulation of various molecules in non-neuronal cells are involved in the development of this pain following trigeminal nerve injury. However, there are many unknown mechanisms underlying the persistent orofacial pain associated with trigeminal nerve injury. In this review, we address recent animal data regarding the involvement of various molecules in the communication of neuronal and non-neuronal cells and examine the possible involvement of ascending pathways in processing pathological orofacial pain. We also address the clinical observations of persistent orofacial pain associated with trigeminal nerve injury and clinical approaches to their diagnosis and treatment.

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口面部神经性疼痛–基础研究及其临床意义–

众所周知，三叉神经损伤会在口面部引起严重的持续性疼痛。这种疼痛很难诊断和治疗。最近，许多动物研究报告说，三叉神经损伤后这种疼痛的发展与周围神经系统和中枢神经系统的重新布线，非神经元细胞的活化以及非神经元细胞中各种分子的上调和下调有关。 。但是，与三叉神经损伤相关的持续性口面疼痛有许多未知的机制。在这篇综述中，我们讨论了有关各种分子参与神经元和非神经元细胞通讯的最新动物数据，并研究了上行通路在处理病理性口腔颌面疼痛中的可能参与。