Recent years have been transformational in regard to the perception of the health risks and benefits of cannabis with increased acceptance of use. This has unintended neurodevelopmental implications given the increased use of cannabis and the potent levels of Δ⁹-tetrahydrocannabinol today being consumed by pregnant women, young mothers and teens. In this Review, we provide an overview of the neurobiological effects of cannabinoid exposure during prenatal/perinatal and adolescent periods, in which the endogenous cannabinoid system plays a fundamental role in neurodevelopmental processes. We highlight impaired synaptic plasticity as characteristic of developmental exposure and the important contribution of epigenetic reprogramming that maintains the long-term impact into adulthood and across generations. Such epigenetic influence by its very nature being highly responsive to the environment also provides the potential to diminish neural perturbations associated with developmental cannabis exposure.

近年来，随着人们越来越多地接受大麻的使用，人们对大麻的健康风险和益处的认识发生了转变。鉴于大麻​​的使用增加和 Δ ^{9的强效水平，这对神经发育产生了意想不到的影响}-今天孕妇、年轻母亲和青少年食用的四氢大麻酚。在这篇综述中，我们概述了产前/围产期和青少年时期大麻素暴露的神经生物学效应，其中内源性大麻素系统在神经发育过程中发挥着重要作用。我们强调突触可塑性受损是发育暴露的特征，以及表观遗传重编程的重要贡献，它维持了对成年期和跨代的长期影响。这种表观遗传影响的本质是对环境高度敏感，也提供了减少与发育大麻暴露相关的神经扰动的潜力。