Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have investigated environmental and health safety aspects of nanomaterials, but the reuse of accumulated data is clearly lagging behind. Here we summarize challenges and provide recommendations for the efficient reuse of nanosafety data, in line with the recently established FAIR (findable, accessible, interoperable and reusable) guiding principles. We describe the FAIR-aligned Nanosafety Data Interface, with an aggregated findability, accessibility and interoperability across physicochemical, bio–nano interaction, human toxicity, omics, ecotoxicological and exposure data. Overall, we illustrate a much-needed path towards standards for the optimized use of existing data, which avoids duplication of efforts, and provides a multitude of options to promote safe and sustainable nanotechnology.

纳米技术是一项关键的使能技术，全球公共资金投资了数十亿欧元，其中包括研究纳米材料的环境和健康安全方面的大型合作项目，但积累的数据的再利用显然滞后。在这里，我们总结了挑战，并根据最近制定的 FAIR（可查找、可访问、可互操作和可重用）指导原则，为有效重用纳米安全数据提供了建议。我们描述了符合 FAIR 的纳米安全数据接口，具有跨物理化学、生物纳米相互作用、人体毒性、组学、生态毒理学和暴露数据的聚合可查找性、可访问性和互操作性。总的来说，我们展示了一条急需的路径，以优化现有数据的使用，从而避免重复工作，并提供多种选择来促进安全和可持续的纳米技术。