The outstanding capacity of aquaporins (AQPs) for mediating highly selective superfast water transport^{1,2,3,4,5,6,7} has inspired recent development of supramolecular monovalent ion-excluding artificial water channels (AWCs). AWC-based bioinspired membranes are proposed for desalination, water purification and other separation applications^{8,9,10,11,12,13,14,15,16,17,18}. While some recent progress has been made in synthesizing AWCs that approach the water permeability and ion selectivity of AQPs, a hallmark feature of AQPs—high water transport while excluding protons—has not been reproduced. We report a class of biomimetic, helically folded pore-forming polymeric foldamers that can serve as long-sought-after highly selective ultrafast water-conducting channels with performance exceeding those of AQPs (1.1 × 10¹⁰ water molecules per second for AQP1), with high water-over-monovalent-ion transport selectivity (~10⁸ water molecules over Cl^– ion) conferred by the modularly tunable hydrophobicity of the interior pore surface. The best-performing AWC reported here delivers water transport at an exceptionally high rate, namely, 2.5 times that of AQP1, while concurrently rejecting salts (NaCl and KCl) and even protons.

水通道蛋白 (AQP) 介导高选择性超快水传输^{1,2,3,4,5,6,7}的出色能力激发了超分子单价离子排除人工水通道 (AWC) 的最新发展。基于 AWC 的仿生膜被提议用于海水淡化、水净化和其他分离应用^{8、9、10、11、12、13、14、15、16、17、18}. 虽然最近在合成接近 AQP 的透水性和离子选择性的 AWC 方面取得了一些进展，但 AQP 的一个标志性特征 - 高水传输同时排除了质子 - 尚未重现。我们报告了一类仿生、螺旋折叠的成孔聚合物折叠体，可作为备受追捧的高选择性超快导水通道，其性能超过 AQP（ AQP1 每秒1.1 × 10 ^{10 个}水分子），具有水对一价离子的高传输选择性（ Cl 上约 10 ^{8个水分子–}离子）由内部孔表面的模块化可调疏水性赋予。此处报道的性能最佳的 AWC 以极高的速率提供水传输，即 AQP1 的 2.5 倍，同时排斥盐（NaCl 和 KCl）甚至质子。