Abstract

The mammalian target of rapamycin (mTOR) signaling pathway is a central regulator of cell metabolism, growth, and survival in response to hormones, growth factors, nutrients, and stress-induced signals. In this review, we analyzed the studies on the molecular abnormalities of the mTOR-associated signaling cascades in autism spectrum disorders (ASDs) and outlined the prospects for the pathogenicity-targeting pharmacotherapeutic approaches to ASDs, in particular syndromic ASDs. Based on available experimental and clinical data, we suggest that very early detection of molecular abnormalities in the ASD risk groups can be facilitated by using peripheral blood platelets. Also, identification of the time window of critical dysregulations in the described pathways in the ASD risk groups might suggest further research directions leading to more efficacious pharmacotherapeutic interventions in ASDs.

中文翻译：

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自闭症中的蛋白磷酸化信号级联：mTOR通路的作用

摘要

雷帕霉素（mTOR）信号转导途径的哺乳动物靶标是细胞代谢，生长和存活的主要调节因子，可响应激素，生长因子，营养素和应激诱导的信号。在这篇综述中，我们分析了自闭症谱系障碍（ASD）中与mTOR相关的信号级联的分子异常的研究，并概述了针对ASD的病原性靶向药物治疗方法的前景，特别是有症状的ASD。根据现有的实验和临床数据，我们建议使用外周血血小板可以促进ASD危险人群中分子异常的早期检测。还，