Introduction

The primary objective of this study was to describe the immediate post-procedural outcomes in dogs with severe pulmonary stenosis that were treated with low-pressure balloon valvuloplasty (BV) at a single institution.

Animals, materials and methods

Retrospective case series; medical records of dogs that underwent BV performed with a balloon dilation catheter >20 mm in diameter and a burst pressure of less than 4 atm (atm) were retrospectively reviewed. Twenty animals were identified fitting the criteria. Pre-procedural and post-procedural echocardiograms and peri-procedural angiograms were reviewed. Procedural success was defined as greater than 50% reduction in echocardiographically derived transpulmonary systolic pressure gradient (TPPG) or post-procedural TPPG of less than 50 mmHg.

Results

The median percent reduction from initial TPPG was 53% (range = 15−90%). Sixty percent of the dogs met the pre-specified criteria for a successful outcome. Post-procedural TPPG was not different based on valve types A or B (p=0.67), presence or absence of additional supravalvular (p=0.23) or subvalvular (p=0.83) obstructive components.

Discussion

The proportion of dogs that reach the successful outcome were not different based on valve type A or B. No relationship was noted between immediate outcomes and bodyweight or pulmonary annulus diameter.

Conclusion

Dogs with severe pulmonic stenosis that underwent low-pressure BV had good immediate outcomes with no difference in outcome based on valve morphology. Further randomized controlled studies are needed to compare the outcomes of different strategies for BV in dogs with large-diameter pulmonary annulus.

中文翻译：

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低压球囊瓣膜成形术治疗 20 只犬重度肺动脉瓣狭窄的即时结果：回顾性单中心病例系列

介绍

本研究的主要目的是描述在单一机构接受低压球囊瓣膜成形术 (BV) 治疗的严重肺动脉狭窄犬的术后即刻结果。

动物、材料和方法

回顾性案例系列；对接受 BV 的狗的医疗记录进行了回顾性审查，球囊扩张导管直径大于 20 毫米，爆裂压力小于 4 个大气压 (atm)。确定了符合标准的 20 只动物。审查了术前和术后超声心动图和围手术期血管造影。手术成功定义为超声心动图衍生的跨肺收缩压梯度 (TPPG) 降低 50% 以上或手术后 TPPG 低于 50 mmHg。

结果

与初始 TPPG 相比的中位数降低百分比为 53%（范围 = 15-90%）。60% 的狗符合预先指定的成功结果标准。基于瓣膜类型 A 或 B ( p =0.67)、是否存在额外的瓣上 ( p =0.23) 或瓣下 ( p =0.83) 阻塞性成分，术后 TPPG 没有差异。

讨论

根据瓣膜类型 A 或 B 的不同，达到成功结果的狗的比例没有差异。直接结果与体重或肺瓣环直径之间没有关系。

结论

接受低压 BV 的患有严重肺动脉狭窄的狗具有良好的即时结果，基于瓣膜形态的结果没有差异。需要进一步的随机对照研究来比较不同策略对大直径肺环狗 BV 的结果。