The nonlinear confusion component is one of an integral part of any modern block cipher. This nonlinear confusion component is used to hides the relationship between the ciphertext and the key. The primary objective of this article is to formulate a new mechanism for the construction this confusion component. Usually substitution box (S-box) is used to achieve this kind of characteristics in block ciphers. We have utilized deoxyribonucleic acid (DNA) sequences for the construction of new S-boxes with optimized cryptographic characteristics. The projected technique fundamentally optimized the DNA sequences along with traditional confusion component to generate a completely new S-box. The obtained S-boxes have the same cryptographic strength as a parent S-box have.

非线性混淆成分是任何现代分组密码的组成部分之一。此非线性混淆组件用于隐藏密文和密钥之间的关系。本文的主要目的是为构造此混淆组件制定新的机制。通常，使用替代盒（S-box）来实现分组密码中的这种特性。我们已经利用脱氧核糖核酸（DNA）序列来构建具有优化密码学特征的新S盒。这项计划技术从根本上优化了DNA序列以及传统的混淆成分，从而产生了一个全新的S-box。所获得的S盒具有与父S盒相同的密码强度。