The evidence regarding a deficiency of manganese (Mn) in humans is scarce. So the aim of this narrative review was to consider the state of the art on the relation between manganese and bone health in humans and the effectiveness of manganese supplementation (alone or with other micronutrients) on bone mineralization. This review included 4 eligible studies. All the literature published is in agreement in showing that osteoporotic women have lower serum Mn levels than women with normal bone mineral density, thus confirming the essential role of manganese in the synthesis of cartilage and bone collagen, as well as in bone mineralization and confirming the studies on the animal model. Considering the human studies that evaluated the effectiveness of an oral Mn supplement for a long period (2 years) on the bone mineral density of menopausal women, both of the clinical trials showed that bone loss was significantly greater in the placebo group than in the group taking supplementation, equal to 5.0 mg Mn/day in the study by Strause, and equal to 2.5 mg Mn/day in the study by Saltman, considering, however, that supplementation was represented by a set of microelements (Mn, copper, and zinc) and by calcium.

关于人类中锰（Mn）缺乏的证据很少。因此，本篇叙事综述的目的是考虑人体中锰与骨骼健康之间的关系以及锰补充剂（单独或与其他微量营养素）对骨骼矿化的有效性的最新技术水平。该评价包括4项符合条件的研究。所有发表的文献都一致表明，骨质疏松症妇女的血清Mn水平低于正常骨矿物质密度的妇女，从而证实了锰在软骨和骨胶原合成以及骨矿化中的重要作用，并证实了动物模型的研究。考虑到人类研究评估了口服锰补充剂对绝经期妇女的骨矿物质密度的长期影响（2年），