Background

Health-related quality of life (HRQL) in stroke survivors is related to numerous factors, but more research is needed to delineate factors related to HRQL in people with aphasia.

Objective

To examine the relationship between HRQL and demographic factors, impairment-based measures, and lesion characteristics in chronic aphasia.

Methods

A total of 41 left-hemisphere stroke survivors with aphasia underwent cognitive testing and magnetic resonance imaging. To address relationships with demographic and impairment-based measures, test scores were entered into a principal component analysis (PCA) and multiple linear regression was performed for overall and domain (physical, communication, psychosocial) scores of the Stroke and Aphasia Quality of Life Scale (SAQOL-39g). Independent variables included factor scores from the PCA, motricity, lesion volume, depressed mood, and demographic variables. To address relationships with lesion location, multivariate support vector regression lesion-symptom mapping (SVR-LSM) was used to localize lesions associated with SAQOL-39g scores.

Results

The PCA yielded 3 factors, which were labeled Language Production, Nonlinguistic Cognition, and Language Comprehension. Multiple linear regression revealed that depression symptoms predicted lower SAQOL-39g average and domain scores. Lower motricity scores predicted lower SAQOL-39g average and physical scores, and lower Language Production factor scores predicted lower communication scores. SVR-LSM demonstrated that basal ganglia lesions were associated with lower physical scores, and inferior frontal lesions were associated with lower psychosocial scores.

Conclusions

HRQL in chronic left-hemisphere stroke survivors with aphasia relates to lesion location, depression symptoms, and impairment-based measures. This information may help identify individuals at risk for specific aspects of low HRQL and facilitate targeted interventions to improve well-being.

中文翻译：

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与健康相关的生活质量领域与慢性失语症的特定缺陷和病变部位有关

背景

中风幸存者的健康相关生活质量 (HRQL) 与许多因素有关，但需要更多的研究来描述与失语症患者的 HRQL 相关的因素。

客观的

研究 HRQL 与人口统计学因素、基于损伤的测量和慢性失语症的病变特征之间的关系。

方法

共有 41 名患有失语症的左脑卒中幸存者接受了认知测试和磁共振成像。为了解决与人口统计和基于损伤的测量的关系，将测试分数输入到主成分分析 (PCA) 中，并对中风和失语症生活质量量表的整体和领域（身体、沟通、社会心理）分数进行多元线性回归(SAQOL-39g)。自变量包括来自 PCA 的因子评分、运动性、病变体积、抑郁情绪和人口统计学变量。为了解决与病变位置的关系，使用多变量支持向量回归病变症状映射 (SVR-LSM) 来定位与 SAQOL-39g 评分相关的病变。

结果

PCA 产生了 3 个因素，分别是语言生产、非语言认知和语言理解。多元线性回归显示，抑郁症状预示着较低的 SAQOL-39g 平均分数和领域分数。较低的运动得分预示着较低的 SAQOL-39g 平均和身体得分，而较低的语言生产因子得分则预示着较低的沟通得分。SVR-LSM 表明基底节病变与较低的身体评分相关，而下额叶病变与较低的心理社会评分相关。

结论

患有失语症的慢性左脑卒中幸存者的 HRQL 与病变部位、抑郁症状和基于损伤的措施有关。这些信息可能有助于识别处于低 HRQL 特定方面风险的个体，并促进有针对性的干预措施以改善幸福感。