Stimuli-responsive or smart nanocarriers are emerging class of materials used for drug delivery and tissue engineering applications. The objective of this study was to develop environment friendly, economic and smart gelatin based hydrogel for controlled delivery of ceftriaxone. Gelatin was modified with furfuryl amine and converted to hydrogel via photo oxidation reaction, initiated with visible light in the presence of crosslinking agent (eosin Y and riboflavin) to enhance the mechanical properties and increase structural integrity of the hydrogel. The conjugated gelatin-furfuryl amine (GFA) was characterized by ¹H NMR and FTIR techniques. An antimicrobial drug (ceftriaxone) was encapsulated in hydrogels systems (HG-E and HG-R) and its encapsulation efficiency was found as 88 % and 74 %, respectively. The in-vitro swelling property and release profile of the drug reveals that the behavior of hydrogel was pH dependent for both the hydrogels systems. Antibacterial study performed on HG-R hydrogel system via disc diffusion method revealed a greater zone of inhibition for Staphylococcus aureus. Findings of the presented work revealed the formation of an excellent, smart hydrogel system using Eosin-Y as cross-linker having greater encapsulation efficiency that can potentially be used for drug delivery application of ceftriaxone to enhance its therapeutic effects.

刺激响应或智能纳米载体是用于药物输送和组织工程应用的一类新兴材料。本研究的目的是开发环境友好、经济且智能的明胶基水凝胶，用于头孢曲松的受控递送。明胶用糠胺修饰并通过光氧化反应转化为水凝胶，在交联剂（曙红 Y 和核黄素）存在下用可见光引发，以提高水凝胶的机械性能和结构完整性。共轭明胶-糠胺 (GFA) 的特点是¹ H NMR 和 FTIR 技术。一种抗菌药物（头孢曲松）被封装在水凝胶系统（HG-E 和 HG-R）中，其封装效率分别为 88% 和 74%。这药物的体外溶胀特性和释放曲线表明，两种水凝胶系统的水凝胶行为都依赖于 pH 值。通过圆盘扩散法对 HG-R 水凝胶系统进行的抗菌研究表明，对金黄色葡萄球菌有更大的抑制区域。所呈现的工作的结果揭示了使用曙红-Y 作为交联剂的优秀智能水凝胶系统的形成，该系统具有更高的包封效率，可潜在用于头孢曲松的药物递送应用以增强其治疗效果。