Illegal drugs and the explosives are harmful chemicals that present both social and national security issues. Existing analytical instruments and methods for identifying these substances are constrained by sensitivity, speed, and portability because of inherent technical defects. Miniaturized photoionization ion trap mass spectrometry is suitable for rapid and on-site identification of illegal drugs and the explosives; however, tandem mass spectrometry and the fragment ions have not been fully investigated. In this article, the abundant fragments of 22 illegal drugs and seven explosives were analyzed successfully using resonance excitation with a miniaturized ion trap mass spectrometer constructed in our laboratory and coupled with flash-thermal-desorption acetone-assisted photoionization. The mass range of the rectilinear ion trap was optimized through experimental mapping of stability diagrams to decrease the effect of the low mass cut-off. The secular frequencies for resonance excitation were simulated and validated using the experimental results. The fragments of illegal drugs and explosives were investigated and imported into a database. By comparing the tandem mass spectrometry fragments and the created database, a seized analyte could be identified within 3 s using a single analysis. This work indicates that ion resonance excitation is an effective approach for rapid analysis of illegal drugs and explosives. Furthermore, combination of a miniaturized ion trap mass spectrometer and compound database is useful for the identification of unknown and known compounds in forensic screening applications.

非法毒品和爆炸物是危害社会和国家安全的化学品。由于固有的技术缺陷，用于识别这些物质的现有分析仪器和方法受到灵敏度、速度和便携性的限制。小型化光电离离子阱质谱适用于非法毒品和爆炸物的快速现场鉴定；然而，串联质谱和碎片离子尚未得到充分研究。在本文中，利用我们实验室构建的小型离子阱质谱仪并结合闪光热解吸丙酮辅助光电离，使用共振激发成功分析了 22 种非法毒品和 7 种爆炸物的丰富碎片。通过稳定性图的实验映射优化了直线离子阱的质量范围，以减少低质量截止的影响。使用实验结果对共振激发的长期频率进行了模拟和验证。非法毒品和爆炸物的碎片被调查并导入数据库。通过比较串联质谱碎片和创建的数据库，可以使用单次分析在 3 秒内识别出被检获的分析物。这项工作表明离子共振激发是快速分析非法毒品和爆炸物的有效方法。此外，小型化离子阱质谱仪和化合物数据库的组合可用于在法医筛查应用中识别未知和已知化合物。