The association of circulating lipids with breast cancer is being debated. The objective of this study was to examine the relationship between abnormal plasma lipids and breast cancer risk in Bangladeshi women. This was a case-control study designed using a population of 150 women (50 women in each group). The lipid levels of women with breast cancer were compared to the lipid levels of women with benign breast disease (control group 1) and healthy women (control group 2). Study samples were collected from the Department of Surgery, Bangabandhu Sheikh Mujib Medical University, for a period of 1 year. Ethical measures were in compliance with the current Declaration of Helsinki. Statistical analysis was performed with SPSS version 26. All of the comparison groups shared similar sociodemographic, anthropometric and obstetric characteristics. The incidence of dyslipidemia was significantly higher in breast cancer patients (96%) than in healthy women (84%) and patients with benign breast disease (82%) (P < 0.05 for both). The levels of total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol among the breast cancer patient group were significantly higher than those among both benign breast disease patients and healthy women (P < 0.05), except for high-density lipoprotein (HDL) cholesterol. Adjusting for other factors, body mass index (BMI) (kg/m2) (> 23) [OR 53.65; 95% CI: 5.70–504.73; P < 0.001] and total cholesterol (mg/dl) (≥ 200) [OR 16.05; 95% CI: 3.13–82.29; P < 0.001] were independently associated with breast cancer. Total cholesterol and BMI are independent predictors of breast cancer risk among Bangladeshi women.

中文翻译：

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孟加拉国女性高脂血症与乳腺癌的关系

循环脂质与乳腺癌的关系正在争论中。本研究的目的是检查孟加拉国女性异常血脂与乳腺癌风险之间的关系。这是一项病例对照研究，设计了 150 名女性（每组 50 名女性）。将乳腺癌女性的血脂水平与良性乳腺疾病女性（对照组 1）和健康女性（对照组 2）的血脂水平进行比较。研究样本是从 Bangabandhu Sheikh Mujib 医科大学外科系收集的，为期 1 年。道德措施符合当前的赫尔辛基宣言。使用 SPSS 26 版进行统计分析。所有对照组都具有相似的社会人口学、人体测量学和产科特征。乳腺癌患者 (96%) 的血脂异常发生率显着高于健康女性 (84%) 和良性乳腺疾病患者 (82%)（两者 P < 0.05）。除高密度脂蛋白外，乳腺癌患者组的总胆固醇、甘油三酯和低密度脂蛋白（LDL）胆固醇水平均显着高于良性乳腺疾病患者和健康女性（P < 0.05）。 HDL）胆固醇。调整其他因素，体重指数 (BMI) (kg/m2) (> 23) [OR 53.65; 95% 置信区间：5.70–504.73；P < 0.001] 和总胆固醇 (mg/dl) (≥ 200) [OR 16.05; 95% 置信区间：3.13–82.29；P < 0.001] 与乳腺癌独立相关。总胆固醇和 BMI 是孟加拉国女性患乳腺癌风险的独立预测因素。