Objective

To evaluate the criterion validity and responsiveness of the steep ramp test (SRT) compared with the cardiopulmonary exercise test (CPET) in evaluating aerobic capacity in survivors of cancer participating in a rehabilitation program.

Design

A prospective cohort study in which survivors of cancer performed an SRT and CPET before (T=0) and after (T=1) a 10-week exercise rehabilitation program. Peak work rate achieved during the SRT (SRT-WRpeak) was compared with peak oxygen consumption measured during the CPET (CPET-Vo₂peak), which is the criterion standard for aerobic capacity. Correlation coefficients were calculated between SRT-WRpeak and CPET-Vo₂peak at T=0 to examine criterion validity and between changes in SRT-WRpeak and CPET-Vo₂peak from T=0 to T=1 to determine responsiveness. Receiver operating characteristic analysis was performed to examine the ability of the SRT to detect a true improvement (6%) in CPET-Vo₂peak.

Setting

University medical center.

Participants

Survivors of cancer (N=106).

Interventions

Exercise rehabilitation.

Main Outcome Measures

Correlation coefficients between CPET-Vo₂peak and SRT-WRpeak and between changes in CPET-Vo₂peak and SRT-WRpeak.

Results

An r of 0.86 (N=106) was found for the relation between SRT-WRpeak and CPET-Vo₂peak at T=0. An r of 0.51 was observed for the relation between changes in SRT-WRpeak and CPET-Vo₂peak (n=59). Receiver operating characteristic analysis showed an area under the curve of 0.74 for the SRT to detect a true improvement in CPET-Vo₂peak, with an optimal cutoff value of +0.26 W/kg (sensitivity 70.7%, specificity 66.7%).

Conclusions

Because SRT-WRpeak and CPET-Vo₂peak were strongly correlated, the SRT seems a valid tool to estimate aerobic capacity in survivors of cancer. The responsiveness to measure changes in aerobic capacity appears moderate. Nevertheless, the SRT seems able to detect improvement in aerobic capacity, with a cutoff value of 0.26 W/kg.

中文翻译：

---

用于评估参与有监督的运动康复计划的癌症幸存者的有氧能力的陡坡试验的标准有效性和响应性

客观的

评估陡坡试验 (SRT) 与心肺运动试验 (CPET) 在评估参与康复计划的癌症幸存者的有氧能力方面的标准有效性和反应性。

设计

一项前瞻性队列研究，其中癌症幸存者在 10 周运动康复计划之前 (T=0) 和之后 (T=1) 进行了 SRT 和 CPET。SRT 期间达到的峰值工作率 (SRT-WRpeak) 与 CPET 期间测得的峰值耗氧量 (CPET-V o ₂峰值) 进行了比较，后者是有氧能力的标准。计算T=0 时SRT-WRpeak 和 CPET-V o ₂峰值之间的相关系数以检查标准有效性，以及计算T=0 到 T=1 时SRT-WRpeak 和 CPET-V o ₂峰值的变化之间的相关系数以确定反应性。进行接受者操作特征分析以检查 SRT 检测 CPET-V o ₂真正改善 (6%) 的能力顶峰。

环境

大学医学中心。

参与者

癌症幸存者（N=106）。

干预措施

运动康复。

主要观察指标

CPET-V之间的相关系数Ò ₂峰和SRT-WRpeak和CPET-V变化之间Ò ₂峰和SRT-WRpeak。

结果

发现T=0 时SRT-WRpeak 和 CPET-V o ₂峰之间的关系的r为 0.86 (N=106) 。一个[R观察到在SRT-WRpeak和变化CPET-V之间的关系的0.51 Ô ₂峰（N = 59）。接受者操作特征分析显示，SRT 检测 CPET-V o ₂峰值真正改善的曲线下面积为 0.74，最佳截止值为 +0.26 W/kg（敏感性 70.7%，特异性 66.7%）。

结论

因为 SRT-WRpeak 和 CPET-V o ₂峰值密切相关，所以 SRT 似乎是估计癌症幸存者有氧能力的有效工具。对测量有氧能力变化的反应似乎中等。尽管如此，SRT 似乎能够检测到有氧能力的改善，截止值为 0.26 W/kg。