Many reviews have summarised the pathology and management of the parasellar region in adult patients, although an analysis of these aspects in the transition years, from puberty onset to the age of peak bone mass, has been lacking. A comprehensive search of English-language original articles, published from 2000 to 2020, was conducted in the MEDLINE database (December 2019 to March 2020). We selected all studies regarding epidemiology, diagnosis and management of the following parasellar lesions: germinoma, craniopharyngioma, Langerhans cell histiocytosis, optic glioma, hypothalamic hamartoma, tuber cinereum hamartoma, cranial chordoma, Rathke cleft cyst, hypophysitis and hypothalamitis during the transition age from childhood to adulthood. In the present review, we provide an overview of the principal parasellar lesions occurring in the transition age. Symptoms are usually a result of the mass effect of the lesions on nearby structures, as well as anterior pituitary deficits. Diabetes insipidus occurs frequently in these patients. In this age group, pubertal developmental disorders may be more evident compared to other stages of life. Parasellar lesions in the transition age mostly include neoplastic lesions such as germinomas, hamartomas, optic gliomas, craniopharyngiomas Langerhans cell histiocytosis and chordomas, and rarely inflammatory lesions (hypophysitis, hypothalamitis). There are limited data on the management of parasellar lesions in the transition age. Endocrine evaluation is crucial for identifying conditions that require hormonal treatment so that they can be treated early to improve the quality of life of the individual patient in this complex age range. The clinical approach to parasellar lesions involves a multidisciplinary effort.

中文翻译：

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过渡年龄鞍旁病变的临床方法

许多综述总结了成年患者鞍旁区域的病理学和管理，尽管一直缺乏对从青春期开始到骨量峰值年龄的过渡时期的这些方面的分析。在 MEDLINE 数据库（2019 年 12 月至 2020 年 3 月）中对 2000 年至 2020 年发表的英文原创文章进行了全面搜索。我们选择了所有关于以下鞍旁病变的流行病学、诊断和管理的研究：生殖细胞瘤、颅咽管瘤、朗格汉斯细胞组织细胞增生症、视神经胶质瘤、下丘脑错构瘤、结节灰质错构瘤、颅脊索瘤、Rathke 裂囊肿、垂体炎和下丘脑炎在从童年到成年的过渡时期。在本综述中，我们概述了过渡时期发生的主要鞍旁病变。症状通常是病变对附近结构的占位效应以及垂体前叶缺陷的结果。这些患者经常发生尿崩症。在这个年龄组中，与其他生命阶段相比，青春期发育障碍可能更为明显。过渡期的鞍旁病变主要包括肿瘤性病变，如生殖细胞瘤、错构瘤、视神经胶质瘤、颅咽管瘤朗格汉斯细胞组织细胞增生症和脊索瘤，很少有炎症性病变（垂体炎、下丘脑炎）。关于过渡时期鞍旁病变的管理数据有限。内分泌评估对于确定需要激素治疗的疾病至关重要，以便可以及早治疗，以改善这一复杂年龄范围内个体患者的生活质量。鞍旁病变的临床方法涉及多学科的努力。