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Cellulose aerogel micro fibers for drug delivery applications
Biomaterials Advances ( IF 5.5 ) Pub Date : 2021-05-20 , DOI: 10.1016/j.msec.2021.112196
Matin Rostamitabar 1 , Raman Subrahmanyam 2 , Pavel Gurikov 2 , Gunnar Seide 3 , Stefan Jockenhoevel 1 , Samaneh Ghazanfari 1
Affiliation  

Textile engineering can offer a multi-scale toolbox via various fiber or textile fabrication methods to obtain woven or nonwoven aerogels with different structural and mechanical properties to overcome the current limitations of polysaccharide-based aerogels, such as poor mechanical properties and undeveloped shaping techniques. Hereby, a high viscous solution of microcrystalline cellulose and zinc chloride hydrate was wet spun to produce mono and multi-filament alcogel microfibers. Subsequently, cellulose aerogel fibers (CAF) were produced and impregnated with model drugs using supercritical CO2 processes. Fibers were characterized in terms of morphology and textural properties, thermal stability, mechanical properties, and in vitro biological and drug release assessments. Loaded and non-loaded CAFs proved to have a macro-porous outer shell and a nano-porous inner core with interconnected pore structure and a specific area in the range of 100–180 m2/g. The CAFs with larger diameter (d ~ 235 μm) were able to form knitted mesh while lower diameter fibers (d ~ 70 μm) formed needle punched nonwoven textiles. Humidity and water uptake assessments indicated that the fibrous structures were highly moisture absorbable and non-toxic with immediate drug release profiles due to the highly open interconnected porous structure of the fibers. Finally, CAFs are propitious to be further developed for biomedical applications such as drug delivery and wound care.



中文翻译:

用于药物输送的纤维素气凝胶微纤维

纺织工程可以通过各种纤维或纺织品制造方法提供多尺度工具箱,以获得具有不同结构和机械性能的机织或非织造气凝胶,以克服目前多糖基气凝胶的局限性,例如较差的机械性能和不发达的成型技术。由此,将微晶纤维素和氯化锌水合物的高粘度溶液湿纺以生产单丝和复丝的醇凝胶微纤维。随后,生产了纤维素气凝胶纤维(CAF),并使用超临界CO 2对其进行了模型药物浸渍。流程。根据形态和质地特性,热稳定性,机械特性以及体外生物和药物释放评估来表征纤维。已证明有载和无载CAF均具有大孔外壳和具有连通孔结构且比表面积在100–180 m 2范围内的纳米多孔内芯。/G。直径较大(d〜235μm)的CAF能够形成编织网,而直径较小的纤维(d〜70μm)可以形成针刺非织造织物。湿度和吸水率评估表明,由于纤维的高度开放的相互连接的多孔结构,纤维结构具有很高的吸湿性,并且无毒,具有立即释放药物的特性。最后,CAF有利于进一步开发用于生物医学应用,例如药物输送和伤口护理。

更新日期:2021-05-26
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