There is clear evidence that hippocampal subfield volumes have partly distinct genetic determinants associated with specific biological processes. The identification of genetic correlates of hippocampal subfield volumes may help to elucidate the mechanisms of neurologic diseases, as well as aging and neurodegenerative processes. However, despite the emerging interest in this area of research, the current knowledge of the genetic architecture of hippocampal subfields has not yet been consolidated. We aimed to provide a review of the current evidence from genetic studies of hippocampal subfields, highlighting current priorities and upcoming challenges. The limited number of studies investigating the influential genetic effects on hippocampal subfields, a lack of replicated results and longitudinal designs, and modest sample sizes combined with insufficient standardization of protocols are identified as the most pressing challenges in this emerging area of research.

有明确的证据表明，海马亚域体积具有与特定生物学过程相关的部分不同的遗传决定因素。海马子域体积的遗传相关性的识别可能有助于阐明神经系统疾病的机制，以及衰老和神经退行性过程。然而，尽管对这一研究领域产生了新的兴趣，但有关海马亚域遗传结构的当前知识尚未得到巩固。我们旨在提供对海马亚领域基因研究的最新证据的综述，重点介绍当前的重点和即将面临的挑战。研究数量有限的研究对海马亚域的遗传影响，缺乏重复的结果和纵向设计，