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New Sulfoxide-Containing Derivatives from the Resin of Ferula sinkiangensis
Planta Medica ( IF 2.7 ) Pub Date : 2021-05-20 , DOI: 10.1055/a-1495-5963 Junchi Wang 1 , Haoli Yan 2 , Xiaoshuang Huo 1 , Lingyu Li 1 , Huijuan Wang 1 , Meng Zhang 1 , Xiaojin Li 3 , Yaqin Zhao 3 , Gang Chen 3 , Jianyong Si 1
Planta Medica ( IF 2.7 ) Pub Date : 2021-05-20 , DOI: 10.1055/a-1495-5963 Junchi Wang 1 , Haoli Yan 2 , Xiaoshuang Huo 1 , Lingyu Li 1 , Huijuan Wang 1 , Meng Zhang 1 , Xiaojin Li 3 , Yaqin Zhao 3 , Gang Chen 3 , Jianyong Si 1
Affiliation
Four undescribed sulfoxide-containing derivatives, sinkiangenoxides A and B, (2Z, 4E)-sinkiangenoxide C, and (2E, 4E)-sinkiangenoxide C (1 – 4), and one known compound, 1-(methylthio)propyl (E)-1-propenyl disulfide (5), were isolated from the resin of Ferula sinkiangensis. Their structures were determined based on spectroscopic methods, including IR, UV, HRESIMS, NMR, and CD analysis. Compounds 2 – 4 showed moderate cytotoxic activities against four human cancer cell lines with IC50 values ranging from 15.0 to 40.3 µM. Sinkiangenoxide B (2) was shown to induce apoptosis in HepG2 cells. In addition, compound 5 effectively attenuated lipopolysaccharide-induced nitric oxide release and TNF-α, IL-1β, IL-6, and IL-10 expression.
更新日期：2021-05-22
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