The marmoset as an important primate model for longitudinal studies of neurocognitive aging,American Journal of Primatology

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The marmoset as an important primate model for longitudinal studies of neurocognitive aging
American Journal of Primatology ( IF 2.0 ) Pub Date : 2021-05-21 , DOI: 10.1002/ajp.23271
Emily S Rothwell ₁ , Carmen Freire-Cobo ₂ , Merina Varghese ₂ , Mélise Edwards ₁ , William G M Janssen ₂ , Patrick R Hof _{2,

3} , Agnès Lacreuse ₁

Affiliation

Age-related cognitive decline has been extensively studied in humans, but the majority of research designs are cross-sectional and compare across younger and older adults. Longitudinal studies are necessary to capture variability in cognitive aging trajectories but are difficult to carry out in humans and long-lived nonhuman primates. Marmosets are an ideal primate model for neurocognitive aging as their naturally short lifespan facilitates longitudinal designs. In a longitudinal study of marmosets tested on reversal learning starting in middle-age, we found that, on average, the group of marmosets declined in cognitive performance around 8 years of age. However, we found highly variable patterns of cognitive aging trajectories across individuals. Preliminary analyses of brain tissues from this cohort also show highly variable degrees of neuropathology. Future work will tie together behavioral trajectories with brain pathology and provide a window into the factors that predict age-related cognitive decline.

中文翻译：

狨猴作为神经认知衰老纵向研究的重要灵长类动物模型

与年龄相关的认知衰退已在人类中进行了广泛研究，但大多数研究设计都是横断面的，并在年轻人和老年人之间进行比较。纵向研究对于捕捉认知老化轨迹的变异性是必要的，但很难在人类和长寿的非人类灵长类动物中进行。狨猴是神经认知衰老的理想灵长类动物模型，因为它们天生的短寿命有利于纵向设计。在一项针对中年开始的逆向学习测试的狨猴纵向研究中，我们发现，平均而言，这组狨猴在 8 岁左右的认知能力下降。然而，我们发现个体之间认知老化轨迹的模式差异很大。对该队列脑组织的初步分析也显示出高度可变的神经病理学程度。未来的工作将把行为轨迹与大脑病理学联系起来，并为预测与年龄相关的认知衰退的因素提供一个窗口。

更新日期：2021-05-21

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