In a recent article published in Molecular Cell, Dai et al. demonstrate that energy stress induced by a ketogenic diet or fasting can enhance checkpoint blockade therapy. Energy stress promotes lysosome-mediated degradation of the immunoinhibitory ligand programmed death-ligand 1 (PDL1) and upregulation of tumor interferon (IFN) responses.

中文翻译：

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饥饿摧毁了肿瘤堡垒

在最近发表在Molecular Cell上的一篇文章中，Dai等人。证明由生酮饮食或禁食引起的能量压力可以增强检查点封锁治疗。能量应激促进溶酶体介导的免疫抑制配体程序性死亡配体 1 (PDL1) 的降解和肿瘤干扰素 (IFN) 反应的上调。