Complex odontoma is a rare odontogenic lesion reported in rodents (order: Rodentia) and odd-toed ungulates (order: Perissodactyla), to name a few, and only in bovine animals of the order Artiodactyla. A 3-year-old female giraffe presented with a steadily proliferating, firm mass in the rostral mandible. With further expansion and ulceration of the mass, the general condition of the giraffe deteriorated and it was euthanized. Post-mortem examination revealed greyish–white tissue with an irregular arrangement of yellowish hard tissue arranged in thin plates and intermingled areas of greyish soft tissue. Histologically, irregular proliferated odontogenic epithelium and mesenchyme, dentin, cementum and empty spaces, suggestive of decalcified enamel, were present. These findings are consistent with a diagnosis of complex odontoma, which should be added to the differential diagnoses of oral tissue proliferations in giraffes. To our knowledge, this is the first description of a complex odontoma in a giraffe.

复杂牙瘤是一种罕见的牙源性病变，见于啮齿动物（目：啮齿目）和奇趾有蹄类动物（目：Perissodactyla），仅举几例，仅在偶蹄目牛类动物中报道。一头 3 岁的雌性长颈鹿在下颌的喙部出现了一个稳定增殖、坚固的肿块。随着肿块的进一步扩大和溃烂，长颈鹿的一般情况恶化，被安乐死。尸检显示灰白色组织，黄色硬组织不规则排列，呈薄板状，灰色软组织混合区域。组织学上，存在不规则增殖的牙源性上皮和间充质、牙本质、牙骨质和空腔，提示牙釉质脱钙。这些发现与复杂牙瘤的诊断一致，这应该被添加到长颈鹿口腔组织增生的鉴别诊断中。据我们所知，这是对长颈鹿复杂牙瘤的首次描述。