All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized cavities are sensitive to optical aberrations as well as manufacturing-induced cavity imperfections which degrade sensor sensitivity and deteriorate photoacoustic image quality. Here we present an experimental method based on adaptive optics that is capable of enhancing the overall sensitivity of Fabry-Pérot based photoacoustic sensors. We experimentally observe clear improvements in photoacoustic signal detection as well as overall image quality after photoacoustic tomography reconstructions when applied to mammalian tissues in vivo.

全光学超声检测具有光声断层扫描的许多独特优势，包括对声场进行高分辨率采样的能力及其与各种其他光学模式的兼容性。然而，基于微型腔体的光学方案对光学像差以及制造引起的腔体缺陷敏感，这会降低传感器灵敏度并降低光声图像质量。在这里，我们提出了一种基于自适应光学的实验方法，该方法能够提高基于法布里-珀罗的光声传感器的整体灵敏度。我们通过实验观察到光声断层扫描重建后光声信号检测和整体图像质量的明显改善，当应用于体内哺乳动物组织时.