An easy and practical synthesis method was developed for the preparation of potentially biologically active 9-amino-7-aryl-6H-benzo[c]chromene-8,10-dicarbonitriles. Starting from chroman-4-one derivatives, aldehydes and malononitrile, the one-pot three-component reaction went on smoothly in the presence of DBU at 60 °C for 32 hours using tetrahydrofuran as solvent. More diverse 9-amino-7-aryl-6H-benzo[c]chromene-8,10-dicarbonitriles were synthesized and separated in good yields. The outstanding advantages of this demonstrated method mainly reflects in the easy access to starting materials, high atom economical manner, simple operation steps and wide applicability.

中文翻译：

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9-Amino-7-aryl-6的直接构建

开发了一种简单实用的合成方法，用于制备具有潜在生物活性的 9-amino-7-aryl-6 H - benzo[ c ]chromene-8,10-dicarbonitriles。以chroman-4-one衍生物、醛类和丙二腈为原料，以四氢呋喃为溶剂，在DBU存在下，在60°C下，一锅三组分反应顺利进行32小时。合成更多样的 9-氨基-7-芳基-6 H-苯并[ c ]色烯-8,10-二甲腈并以良好的产率分离。该方法的突出优点主要体现在原料易得、原子经济性高、操作步骤简单、适用性广等方面。