Abstract

Objective

To compare the efficacy and safety of the treatment of vulvar lichen simplex chronicus (VLSC) using high-intensity focused ultrasound (HIFU) at different powers.

Methods

This retrospective study included 152 patients with VLSC. Among these patients, 70 were treated with HIFU at low power (level 2), and 82 were treated at normal power (level 3). The treatment responses, recurrence rates and intra- and postoperative complications were all compared.

Results

No statistically significant differences were found between the two groups in age, disease course, menopause status, lesion size and severity of symptoms. All patients received one session of HIFU therapy, and the treatment process was successful. No difference was found in the total response rate between the two groups at 1 (85.7% versus 87.8%, p = .35), 6 (80% versus 80.5%, p = .65) and 12 (80% versus 80.5%, p = .73) months after HIFU therapy. No significant difference was observed in the recurrence rate between the two groups at 6 (5.7% versus 9.8%, p = .36) and 12 (22.9% versus 26.8%, p = .57) months after HIFU treatment. Patients in the low-power group had a lower incidence of blisters (10% versus 23.3%, p = .04).

Conclusion

Based on our results, low-power HIFU treatment can achieve a therapeutic effect similar to normal power HFU treatment for VLSC, but its incidence of side effects is lower.

中文翻译：

---

高强度聚焦超声在不同功率下治疗慢性外阴扁平苔藓的疗效和安全性比较

摘要

客观的

为了比较在不同功率下使用高强度聚焦超声（HIFU）治疗慢性外阴单纯性苔藓（VLSC）的疗效和安全性。

方法

这项回顾性研究包括152例VLSC患者。在这些患者中，有70例接受了低功率HIFU治疗（2级），而82例接受了正常功率的3级治疗。比较治疗反应，复发率以及术中和术后并发症。

结果

两组在年龄，病程，更年期状态，病变大小和症状严重程度方面均无统计学差异。所有患者均接受了一次HIFU治疗，治疗过程成功。两组之间的总缓解率无差异，分别为1（85.7％对87.8％，p  = 0.35），6（80％对80.5％，p  = 0.65）和12（80％对80.5％，p  = .73）HIFU治疗后数月。两组之间的复发率没有显着差异，分别为6（5.7％vs 9.8％，p  = 0.36）和12（22.9％vs 26.8％，p）。 = HIFU治疗后的0.57个月）。低功率组的水泡发生率较低（10％比23.3％，p  = .04）。

结论

根据我们的结果，低功率HIFU治疗可达到类似于VLSC的常规功率HFU治疗的治疗效果，但其副作用发生率较低。