This study investigates the curative response of ethanol extract of Cassia sieberiana leaves (EECSL) on testosterone-induced benign prostatic hyperplasia (BPH). Thirty rats of 11–12 weeks old weighing 120–160 g were grouped into six of five rats each. Group 1 was the normal control; groups 2–6 were induced with testosterone (5 mg/kg body weight) for 21 days following standard procedures. Group 2 serves as BPH-control, groups 3 received finasteride while 4–6 received orally 100, 300, and 500 mg/kg of EECSL, respectively for 14 days. Biochemical and BPH indices were analyzed. Oral administration of EECSL showed a decrease in prostate weight, Prostate-specific antigen (PSA), testosterone and dihydrotestosterone (DHT), triacylglycerol (TAG), total cholesterol (TC), low-density lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) whereas an elevation in high-density lipoprotein (HDL), GSH and likewise antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activities were recorded. The histology photomicrographs showed that EECSL restored lesions of testosterone induction in the treated groups. Our study reveals that EECSL exerts potent on BPH, hypolipidaemic, and antioxidant potentials and justifies the claims by the traditional doctors in BPH management.

本研究调查决明子乙醇提取物的疗效叶（EECSL）参与睾丸激素诱发的前列腺增生（BPH）。将11-12周大的120-160 g体重的30只大鼠分为五只大鼠中的六只。第1组为正常对照组。按照标准程序，第2-6组用睾丸激素（5 mg / kg体重）诱导21天。第2组用作BPH对照，第3组接受非那雄胺，而4-6组分别口服100、300和500 mg / kg EECSL，共14天。生化和BPH指数进行了分析。口服EECSL显示前列腺重量，前列腺特异性抗原（PSA），睾丸激素和二氢睾丸激素（DHT），三酰甘油（TAG），总胆固醇（TC），低密度脂蛋白（LDL），丙二醛（MDA），天冬氨酸转氨酶（AST），和丙氨酸氨基转移酶（ALT），而高密度脂蛋白（HDL），谷胱甘肽（GSH）以及类似的抗氧化酶超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性均升高。组织学显微照片显示，EECSL在治疗组中恢复了睾丸激素诱导的损伤。我们的研究表明，EECSL在BPH，降血脂和抗氧化剂方面具有强大的作用，并证明了传统医生在BPH管理中的主张是合理的。