Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided in discovering several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial, antitubercular, antibacterial, and anticancer activities. Indole-2,3-dione and their derivatives have diverse pharmacological properties and have a prominent role in the discovery of new drugs. To understand the various approaches for designing new molecules based on isatin nucleus analysis of various pharmacophore hybrids, spacers/linkers between pharmacophores and isatin for hybridization and their biological activities are important. This review discusses the progress in developing isatin hybrids as biologically effective agents and their crucial aspects of design and structure-activity relationships.

杂交是设计可有效用于治疗人类已知致命疾病的分子的重要策略。分子杂种及其药理研究有助于发现具有抗HIV，抗疟疾，抗结核，抗菌和抗癌活性的几种有效的靛红（吲哚2、3二酮）衍生物。吲哚-2，3-二酮及其衍生物具有多种药理特性，并且在新药的发现中具有重要作用。为了理解基于对各种药效基团杂合体的伊斯汀核分析而设计新分子的各种方法，药效基团与伊斯汀之间的用于杂交及其生物活性的间隔子/接头是重要的。