This report describes the phenotypic characteristics of a novel fungal species, isolated from a prosthetic hip infection. The patient, who had undergone multiple total hip arthroplasties due to Legg-Calvé-Perthes disease, presented with continued fever and wound dehiscence. Findings upon incision and draining were notable for necrotic tissue and a sinus tract from the fluid collection. Intraoperative cultures were positive for a sterile filamentous fungus. BLASTn results following DNA sequencing placed the isolate within the family Chaetomiaceae close to the genera Madurella, Canariomyces, Stolonocarpus, Stellatospora, Ovatospora, Carteria and Melanocarpus. Phylogenetic analysis demonstrated that the isolate was a new thielavia-like species, Pseudocanariomyces americanus. Antifungal susceptibility was performed, and low minimum inhibitory concentrations were observed with amphotericin B, itraconazole, posaconazole, and voriconazole. The patient was initially treated with voriconazole but was switched to posaconazole secondary to a photosensitivity reaction. Acceptable posaconazole trough concentrations were achieved, and the patient remained stable without pain or drainage from her surgical incision.

这份报告描述了一种从假体髋关节感染中分离出来的新型真菌的表型特征。该患者因 Legg-Calvé-Perthes 病接受了多次全髋关节置换术，出现持续发热和伤口裂开。切开和引流时发现坏死组织和积液中的窦道。术中培养为无菌丝状真菌阳性。下列的DNA测序结果的BLASTN放置分离物的家庭毛壳菌内靠近属马杜拉分支菌属，Canariomyces，Stolonocarpus，Stellatospora，Ovatospora，Carteria和Melanocarpus. 系统发育分析表明，该分离物是一种新的类thielavia物种，美洲假单胞菌。进行了抗真菌药敏试验，观察到两性霉素 B、伊曲康唑、泊沙康唑和伏立康唑的最低抑菌浓度较低。患者最初接受伏立康唑治疗，但因光敏反应继发使用泊沙康唑治疗。达到了可接受的泊沙康唑谷浓度，患者保持稳定，手术切口无疼痛或引流。